Jiva T M, Jacoby H M, Weymouth L A, Kaminski D A, Portmore A C
Department of Internal Medicine, University of Rochester School of Medicine and Dentistry, New York, USA.
Clin Infect Dis. 1997 Feb;24(2):226-32.
Mycobacterium xenopi is a recognized cause of smoldering pulmonary disease in patients with chronic lung disease. This organism is frequently isolated from respiratory specimens from individuals infected with human immunodeficiency virus (HIV) and is often considered nonpathogenic. Cases of pulmonary and disseminated M. xenopi disease have been described in patients with HIV infection and other immunodeficiencies. Many physicians are unaware of the clinical significance of M. xenopi isolation. Whether this organism represents a commensal or a pathogen capable of causing considerable morbidity and mortality is not fully understood. In this study, we investigated the clinical significance of M. xenopi isolation and explored the clinical spectrum of M. xenopi disease. Clinical illness occurred both in elderly people with chronic lung disease and in young individuals with HIV infection. The repeated isolation of M. xenopi in association with pulmonary lesions suggests significant infection and mandates further workup and therapy.
偶发分枝杆菌是慢性肺病患者隐匿性肺部疾病的一个公认病因。这种微生物经常从感染人类免疫缺陷病毒（HIV）的个体的呼吸道标本中分离出来，并且通常被认为是非致病性的。在HIV感染和其他免疫缺陷患者中已有肺部和播散性偶发分枝杆菌病的病例报道。许多医生并不知晓偶发分枝杆菌分离的临床意义。这种微生物是一种共生菌还是一种能够导致相当高发病率和死亡率的病原体，目前尚未完全明确。在本研究中，我们调查了偶发分枝杆菌分离的临床意义，并探讨了偶发分枝杆菌病的临床谱。临床疾病在患有慢性肺病的老年人和感染HIV的年轻人中均有发生。偶发分枝杆菌与肺部病变相关的反复分离提示有严重感染，需要进一步检查和治疗。
