Kuchibatla Shankar Srinivas, Cheema Sofia Akram, Chakravarthy Kripa S, Sayeh Hany George El
North Yorkshire and York PCT, Psychiatry, Briary Wing, Harrogate District Hospital, Lancaster Park Road, Harrogate HG2 7SX, UK.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.07.2008.0429. Epub 2009 May 20.
A 32-year-old male patient with a history of treatment resistant paranoid schizophrenia developed neuroleptic malignant syndrome (NMS) during changeover of his antipsychotic medication from zuclopenthixol depot to clozapine. This case highlights the difficulties of cross-tapering two antipsychotics-that is, converting from a typical depot medication to an oral atypical antipsychotic.
一名32岁的男性患者,有难治性偏执型精神分裂症病史,在抗精神病药物从长效珠氯噻醇转换为氯氮平的过程中发生了抗精神病药恶性综合征(NMS)。该病例凸显了两种抗精神病药物交叉减量的困难,即从一种典型的长效药物转换为口服非典型抗精神病药物的困难。