Gossett K A, French D D, Cleghorn B, Church G E
Department of Veterinary Pathology, Louisiana State University, Baton Rouge 70803.
Am J Vet Res. 1990 Sep;51(9):1370-4.
Hypertonic NaHCO3 infusion caused blood volume expansion, increased blood bicarbonate concentration, and delayed the onset of hypophosphatemia in ponies with endotoxemia. However, NaHCO3 infusion did not normalize blood pH, and it increased blood L-lactate concentration, and caused hypokalemia, hypernatremia, and hyperosmolality. The deleterious effects of NaHCO3 infusion in endotoxemia ponies outweighed the beneficial effects. The role of hypertonic NaHCO3 given IV for treatment of endotoxemia in equids must be reevaluated.
输注高渗碳酸氢钠会导致血容量扩张、血液碳酸氢盐浓度升高，并延缓内毒素血症小马低磷血症的发生。然而，输注碳酸氢钠并未使血液pH值恢复正常，反而增加了血液L-乳酸浓度，并导致低钾血症、高钠血症和高渗状态。在内毒素血症小马中，输注碳酸氢钠的有害作用超过了有益作用。静脉注射高渗碳酸氢钠治疗马属动物内毒素血症的作用必须重新评估。
