难治性免疫性血小板减少性紫癜长期临床病程中发生的多发性骨髓瘤：一例报告并文献复习
Multiple myeloma developing during long-term clinical course of refractory immune thrombocytopenic purpura: a case report and review of literature.
作者信息
Yao Han, Zhang Xi, Liu Jia, Zhu Lidan, Chen Guo, Wu Sha, Gao Lei
机构信息
Department of Hematology, Xinqiao Hospital, Third Military Medical University Chongqing, China.
出版信息
Int J Clin Exp Pathol. 2015 Nov 1;8(11):15429-32. eCollection 2015.
Abstract
Immune thrombocytopenia (ITP) is an acquired, immune-mediated disease that is characterized by increased destruction of platelets by autoantibodies. Although the onset of the disease and clinical course are highly variable, the disease typically has a benign course. ITP associated with multiple myeloma (MM) has been rarely reported; it is even rarer for MM to develop during a long-term ITP (almost 20 years). Here, we first report on a case with a 20-year long clinical course of refractory ITP followed by newly diagnosed MM.
摘要
免疫性血小板减少症（ITP）是一种获得性免疫介导性疾病，其特征是自身抗体导致血小板破坏增加。尽管该疾病的起病和临床病程高度可变，但通常呈良性病程。与多发性骨髓瘤（MM）相关的ITP鲜有报道；MM在长期ITP（近20年）病程中发生则更为罕见。在此，我们首次报告一例难治性ITP长达20年临床病程后新发MM的病例。
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