Yao Han, Zhang Xi, Liu Jia, Zhu Lidan, Chen Guo, Wu Sha, Gao Lei
Department of Hematology, Xinqiao Hospital, Third Military Medical University Chongqing, China.
Int J Clin Exp Pathol. 2015 Nov 1;8(11):15429-32. eCollection 2015.
Immune thrombocytopenia (ITP) is an acquired, immune-mediated disease that is characterized by increased destruction of platelets by autoantibodies. Although the onset of the disease and clinical course are highly variable, the disease typically has a benign course. ITP associated with multiple myeloma (MM) has been rarely reported; it is even rarer for MM to develop during a long-term ITP (almost 20 years). Here, we first report on a case with a 20-year long clinical course of refractory ITP followed by newly diagnosed MM.
免疫性血小板减少症（ITP）是一种获得性免疫介导性疾病，其特征是自身抗体导致血小板破坏增加。尽管该疾病的起病和临床病程高度可变，但通常呈良性病程。与多发性骨髓瘤（MM）相关的ITP鲜有报道；MM在长期ITP（近20年）病程中发生则更为罕见。在此，我们首次报告一例难治性ITP长达20年临床病程后新发MM的病例。
