Krishna K Ananda, Krishna K Sai, Berrocal Ruben, Rao K S, Sambasiva Rao K R S
Department of Biotechnology, Acharya Nagarjuna University, Guntur - 522 510, India.
J Pharm Bioallied Sci. 2011 Apr;3(2):182-8. doi: 10.4103/0975-7406.80761.
Permanent loss of cardiomyocytes and scar tissue formation after myocardial infarction (MI) results in an irreversible damage to the cardiac function. Cardiac repair (replacement, restoration, and regeneration) is, therefore, essential to restore function of the heart following MI. Existing therapies lower early mortality rates, prevent additional damage to the heart muscle, and reduce the risk of further heart attacks. However, there is need for treatment to improve the infarcted area by replacing the damaged cells after MI. Thus, the cardiac tissue regeneration with the application of stem cells may be an effective therapeutic option. Recently, interest is more inclined toward myocardial regeneration with the application of stem cells. However, the potential benefits and the ability to improve cardiac function with the stem cell-based therapy need to be further addressed. In this review, we focus on the clinical applications of stem cells in the cardiac repair.
心肌梗死（MI）后心肌细胞的永久性丧失和瘢痕组织形成会导致心脏功能的不可逆损伤。因此，心脏修复（替代、恢复和再生）对于心肌梗死后恢复心脏功能至关重要。现有疗法可降低早期死亡率，防止对心肌的进一步损伤，并降低再次心脏病发作的风险。然而，需要一种治疗方法来通过在心肌梗死后替换受损细胞来改善梗死区域。因此，应用干细胞进行心脏组织再生可能是一种有效的治疗选择。最近，人们对应用干细胞进行心肌再生的兴趣更大。然而，基于干细胞的疗法的潜在益处以及改善心脏功能的能力仍需进一步探讨。在本综述中，我们重点关注干细胞在心脏修复中的临床应用。
