由白地霉CCT 1205和粘红酵母CCT 2182介导还原2-卤代-1-(4-取代苯基)乙酮得到的手性药物中间体
Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182.
作者信息
Fardelone Lucídio C, Rodrigues J Augusto R, Moran Paulo J S
机构信息
Institute of Chemistry, University of Campinas, CP 6154, 13084-971 Campinas, SP, Brazil.
出版信息
Enzyme Res. 2011;2011:976368. doi: 10.4061/2011/976368. Epub 2011 Jun 2.
Enantioselective reductions of p-R(1)-C(6)H(4)C(O)CH(2)R(2) (R(1) = Cl, Br, CH(3), OCH(3), NO(2) and R(2) = Br, Cl) mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182 afforded the corresponding halohydrins with complementary R and S configurations, respectively, in excellent yield and enantiomeric excesses. The obtained (R)- or (S)-halohydrins are important building blocks in chemical and pharmaceutical industries.
由白地霉CCT 1205和粘红酵母CCT 2182介导的对p-R(1)-C(6)H(4)C(O)CH(2)R(2)（R(1) = Cl、Br、CH(3)、OCH(3)、NO(2)且R(2) = Br、Cl）的对映选择性还原反应分别以优异的产率和对映体过量得到了具有互补R和S构型的相应卤代醇。所得到的(R)-或(S)-卤代醇是化学和制药工业中的重要构建单元。
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