Satybaldina N K, Frolov V A
Biull Eksp Biol Med. 1990 Jun;109(6):527-9.
The effects of complex vitamins A and E on electrophysiological characteristics was investigated on frog cardiomyocytes. Large doses of vitamins A and E decreased the steepness of the action potential (AP) front, decreased the spike amplitude, shortened the plateau, decreased the steepness in the last phase of AP-repolarization, and decreased the rest potential level but considerably increased overshoot. The Ap-duration decreased noticeably. Small doses of vitamins decreased the spike amplitude, shortened the plateau, decreased the Ap-duration. We assume that complex of vitamins A and E can affect the cardiomyocyte membrane transport function, mainly due to the suppression of the slow membrane channels. The AP-front increase is less steep under the influence of vitamins. It is shown that the 0-phase depolarization speed decreases due to the inhibition of sodium channels.
研究了复合维生素A和E对蛙心肌细胞电生理特性的影响。大剂量的维生素A和E降低了动作电位（AP）上升沿的斜率，降低了锋电位幅度，缩短了平台期，降低了AP复极化最后阶段的斜率，并降低了静息电位水平，但超射值显著增加。AP时程明显缩短。小剂量的维生素降低了锋电位幅度，缩短了平台期，缩短了AP时程。我们认为，维生素A和E的复合物可影响心肌细胞膜转运功能，主要是由于对慢膜通道的抑制作用。在维生素的影响下，AP上升沿的增加不那么陡峭。结果表明，由于钠通道的抑制，0期去极化速度降低。
