Satybaldina N K, Frolov V A
Biull Eksp Biol Med. 1990 Feb;109(2):115-7.
The effects of the vitamin A lysosomal membrane labilizator on electrophysiological characteristics was investigated on frog cardiomyocytes. Large and small doses of vitamin A produced qualitatively identical effects: decrease of the steepness of action potential (AP) front, decrease of the spike amplitude, shortening of the plateau, decrease of the steepness in the last phase of AP-repolarization. The AP-duration decreased considerably. Large doses of the vitamin also reduced the rest potential level and insignificantly increased the heart contractions frequency. We assume that vitamin A can affect the cardiomyocyte surface membrane permeability, thereby decreasing its excitability due to suppression of the sodium and potassium.
研究了维生素A溶酶体膜稳定剂对蛙心肌细胞电生理特性的影响。大剂量和小剂量的维生素A产生了定性相同的效果：动作电位（AP）上升前沿斜率降低、锋电位幅度降低、平台期缩短、AP复极化最后阶段斜率降低。AP持续时间显著缩短。大剂量的该维生素还降低了静息电位水平，并轻微增加了心脏收缩频率。我们认为维生素A可影响心肌细胞膜通透性，从而通过抑制钠和钾来降低其兴奋性。
