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[遗传性动脉高血压大鼠的内分泌-代谢关系]

[Endocrine-metabolic relations in rats with genetic arterial hypertension].

作者信息

Shorin Iu P, Markel' A L, Seliatitskaia V G, Pal'chikova N A, Grinberg P M, Amstislavskiĭ S Ia

出版信息

Biull Eksp Biol Med. 1990 Jun;109(6):575-6.

PMID:2168774
Abstract

Levels of triiodothyronine, thyroxine, insulin, glucose and free fatty acids in the blood; contents of adrenaline, noradrenaline in adrenals and glycogen in the liver; activity of phenylethanolamine-N-methyltransferase in adrenals, hexokinase and glucose-6-phosphatase in the liver were studied in male Wistar rats and rats with inherited stress-induced arterial hypertension /ISIAH/. It was found that genetically caused rise of hypophyseal-thyroid systems activity in ISIAH-rats leads to a decrease of insulin blood level, activation of lipolysis and breach of glucose tolerance.

摘要

对雄性Wistar大鼠和遗传性应激诱导性动脉高血压(ISIAH)大鼠的血液中三碘甲状腺原氨酸、甲状腺素、胰岛素、葡萄糖和游离脂肪酸水平;肾上腺中肾上腺素、去甲肾上腺素含量以及肝脏中糖原含量;肾上腺中苯乙醇胺 - N - 甲基转移酶活性、肝脏中己糖激酶和葡萄糖 - 6 - 磷酸酶活性进行了研究。结果发现,ISIAH大鼠中垂体 - 甲状腺系统活性的遗传性升高导致胰岛素血液水平降低、脂肪分解激活和葡萄糖耐量破坏。

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