Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany.
Parkinsons Dis. 2011;2011:540843. doi: 10.4061/2011/540843. Epub 2011 May 23.
Comparable to Alzheimer's disease, mild cognitive impairment in Parkinson's disease (PD-MCI) is associated with an increased risk for dementia. However different definitions of PD-MCI may have varying predictive accuracy for dementia. In a cohort of 101 nondemented Parkinson patients who underwent neuropsychological testing, the frequency of PD-MCI subjects and PD-MCI subtypes (i.e., amnestic/nonamnestic) was determined by use of varying healthy population-based cut-off values. We also investigated the association between defined PD-MCI groups and ADL scales. Varying cut-off values for the definition of PD-MCI were found to affect frequency of PD-MCI subjects (9.9%-92.1%) and, maybe more important, lead to a "shift" of proportion of detected PD-MCI subtypes especially within the amnestic single-domain subtype. Models using a strict cut-off value were significantly associated with lower ADL scores. Thus, the use of defined cut-off values for the definition of PD-MCI is highly relevant for comparison purposes. Strict cut-off values may have a higher predictive value for dementia.
与阿尔茨海默病类似，帕金森病患者的轻度认知障碍（PD-MCI）与痴呆的风险增加相关。然而，PD-MCI 的不同定义可能对痴呆的预测准确性有所不同。在一项对 101 名非痴呆帕金森病患者进行神经心理学测试的队列研究中，通过使用不同的基于健康人群的截断值来确定 PD-MCI 受试者和 PD-MCI 亚型（即遗忘型/非遗忘型）的频率。我们还研究了定义的 PD-MCI 组与 ADL 量表之间的关联。发现用于定义 PD-MCI 的不同截断值会影响 PD-MCI 受试者的频率（9.9%-92.1%），也许更重要的是，导致检测到的 PD-MCI 亚型的比例发生“转移”，特别是在遗忘型单一域亚型中。使用严格截断值的模型与较低的 ADL 评分显著相关。因此，为定义 PD-MCI 而定义的截断值的使用对于比较目的非常重要。严格的截断值可能对痴呆具有更高的预测价值。
