Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168, Rome, Italy.
Neurochem Res. 2011 Aug;36(8):1490-500. doi: 10.1007/s11064-011-0478-2. Epub 2011 Jun 18.
Trimethyltin (TMT), an organotin compound considered a useful tool to obtain an experimental model of neurodegeneration, exhibits neurotoxicant effects selectively localised in the limbic system and especially in the hippocampus, which are different in the rat and in mice. In the rat hippocampus, we investigated the expression of aldehyde 4-hydroxynonenal, a major bioactive marker of membrane lipid peroxidation, heat shock protein (HSP) 110/105 family members, markers of oxidative stress, and the neuroinflammatory marker cyclooxygenase-2 after TMT-intoxication at various time points after treatment. Our data show that TMT-induced neurodegeneration in the rat hippocampus is associated specifically with oxidative stress and lipid peroxidation, but not with HSP expression, indicating species-specific differences in the neurotoxicity of TMT between rats and mice.
三甲基锡（TMT）是一种有机锡化合物，被认为是获得神经退行性变实验模型的有用工具，具有神经毒性作用，选择性地定位于边缘系统，特别是海马体，在大鼠和小鼠中有所不同。在大鼠海马体中，我们研究了醛 4-羟基壬烯醛（膜脂质过氧化的主要生物活性标志物）、热休克蛋白（HSP）110/105 家族成员（氧化应激标志物）和神经炎性标志物环加氧酶-2 在 TMT 中毒后的不同时间点的表达。我们的数据表明，TMT 诱导的大鼠海马体神经退行性变与氧化应激和脂质过氧化有关，但与 HSP 表达无关，这表明大鼠和小鼠 TMT 神经毒性的物种特异性差异。
