Tsubura A, Morii S, Moriyama T, Matsuzawa A
Department of Pathology, Kansai Medical University, Osaka, Japan.
Cancer Lett. 1990 Aug;53(1):73-8. doi: 10.1016/0304-3835(90)90013-n.
To investigate the effects of the T-cell deprivation on viral mammary tumorigenesis, two double congenic mouse strains of the DDD genetic background, DDD/1-Mtv-2/Mtv-2, nu/nu and DDD/1-Mtv-2/Mtv-2, nu/+, were produced by the cross between DDD/1-Mtv-2/Mtv-2 (DDD-Mtv-2) and DDD/1-nu/nu mice, followed by repeated intercross breedings. Expression of the mouse mammary tumor virus (MTV)-gp52 antigen was demonstrated in the mammary glands of mice from 14 days on, in both -nu/nu and -nu/+ females. Mammary gland development was comparable in both strains, but, the incidence of mammary cancer was lower in the T-cell-deprived mice.
为了研究T细胞缺失对病毒性乳腺肿瘤发生的影响，通过将DDD/1-Mtv-2/Mtv-2（DDD-Mtv-2）与DDD/1-nu/nu小鼠杂交，随后进行反复回交育种，培育出了两个具有DDD遗传背景的双基因小鼠品系，即DDD/1-Mtv-2/Mtv-2，nu/nu和DDD/1-Mtv-2/Mtv-2，nu/+。从14日龄起，在nu/nu和nu/+雌性小鼠的乳腺中均证实了小鼠乳腺肿瘤病毒（MTV）-gp52抗原的表达。两个品系的乳腺发育情况相当，但T细胞缺失的小鼠患乳腺癌的发生率较低。
