Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Mária utca 41, 1085, Budapest, Hungary.
Pathol Oncol Res. 2012 Apr;18(2):535-8. doi: 10.1007/s12253-011-9405-8. Epub 2011 Jun 19.
The 15-year-old male patient presented several 2-6 mm large livid reddish-yellowish, shiny, compact papules on the head, trunk and extremities, which had developed within the last 4 months. Histology showed normal epidermis with dense dermal infiltrate of histiocytes accompanied by few eosinophils, Touton or foamy giant cells. The histiocytes were S100 positive, CD1a negative and did not contain Birbeck granules ultrastructurally. Chest X ray, EEG, skull MRI did not show pathology. Opthalmology, neurology, oto-rhino-laryngology did not reveal alterations. Based upon the clinical symptoms and the histopathology, the diagnosis of indeterminate cell histiocytosis was confirmed. Cryotherapy and cauterization did not stop the progression of the disease, however, under thalidomide treatment no new symptoms developed and the lesions healed with pigmentation.
这位 15 岁的男性患者头部、躯干和四肢出现了几个 2-6 毫米大小的暗紫红色、有光泽、紧实的丘疹，这些丘疹在过去 4 个月内发展而来。组织学显示正常表皮，真皮内有密集的组织细胞浸润，伴有少量嗜酸性粒细胞、 Touton 或泡沫状巨细胞。组织细胞 S100 阳性，CD1a 阴性，超微结构中不含 Birbeck 颗粒。胸部 X 光、脑电图、颅骨 MRI 未显示病理学改变。眼科、神经科、耳鼻喉科未发现改变。根据临床症状和组织病理学，诊断为未确定细胞组织细胞增生症。冷冻疗法和烧灼未能阻止疾病的进展，然而，在沙利度胺治疗下，没有出现新的症状，病变愈合并伴有色素沉着。
