Department of Haematology, Birmingham Children's Hospital, Birmingham, UK.
Br J Haematol. 2011 Aug;154(4):482-5. doi: 10.1111/j.1365-2141.2011.08752.x. Epub 2011 Jun 21.
Clofarabine is a second-generation purine nucleoside analogue, which has shown promising activity in relapsed and refractory paediatric acute lymphoblastic leukaemia (ALL). This report summarizes the early United Kingdom experience of clofarabine for the treatment of paediatric ALL in 23 patients, outside of the context of a clinical trial. Our results demonstrated that clofarabine-based chemotherapy regimes were effective and well-tolerated in this heavily pre-treated group, with an overall response rate of 67% when used in combination regimes. Responses were seen in both B and T cell disease and in patients with adverse cytogenetics.
氯法拉滨是第二代嘌呤核苷类似物，在复发和难治性儿童急性淋巴细胞白血病（ALL）中显示出有前景的活性。本报告总结了氯法拉滨在 23 名患儿中的英国初步经验，这些患儿都在临床试验之外接受了治疗。我们的结果表明，氯法拉滨联合化疗方案在这些预处理后的患儿中有效且耐受良好，当与联合方案一起使用时，总反应率为 67%。在 B 细胞和 T 细胞疾病以及具有不良细胞遗传学的患者中均观察到了缓解。
