Oral and Maxillofacial Pathology, Faculty of Dentistry, Cairo University, 11 el Saraya Street, Manyal, Cairo, Egypt.
Head Neck Pathol. 2024 Aug 13;18(1):76. doi: 10.1007/s12105-024-01676-9.
Despite their rarity, malignant odontogenic tumors (MOT) represent an important group of oral lesions characterized by their variable clinical presentations and sometimes unexpected biological behavior.
The purpose of this retrospective cross-sectional study was to evaluate the number, types, and frequency of MOT and to investigate the relative rate of malignant transformation in recurrent odontogenic tumors (OT).
The records of patients diagnosed with OT in the hospital of the Faculty of Dentistry, Cairo University, were reviewed over 10 years (2013-2022). The OT were investigated for frequency, age, gender, site, and recurrence. The data were recorded and then analyzed using SPSS software version 25.
Among 5543 oral excisions, 357 cases of them were OT, including 336 benign (94.1%) and 21 malignant neoplasms (5.9%). Among the odontogenic malignancies, 18 lesions (85.7%) appeared de novo, and 3 lesions (14.3%) developed as recurrent of previously classified benign tumors. A high incidence was observed in the middle and old age groups (90.4%) with a median age being 42. Slight male predilection (1.3:1) was noticed. The mandible was the highly affected site but all recurrent cases were diagnosed in the maxilla as ghost cell odontogenic carcinoma (n = 2, 66.6%) and primary intraosseous carcinoma (n = 1, 33.3%).
Retrospective analysis of the relative frequency of MOT and the documentation of the unusual recurrence of benign OT as a malignancy enhances our understanding of OT behavior and the need for appropriate therapy and clinical follow-up.
尽管恶性牙源性肿瘤（MOT）较为罕见，但它们是一组具有重要特征的口腔病变，其临床表现多样，有时生物学行为出乎意料。
本回顾性横断面研究旨在评估 MOT 的数量、类型和频率，并研究复发性牙源性肿瘤（OT）中恶性转化的相对发生率。
回顾性分析 2013 年至 2022 年期间在开罗大学牙科学院医院诊断为 OT 的患者的病历。研究 OT 的频率、年龄、性别、部位和复发情况。将数据记录下来，然后使用 SPSS 软件版本 25 进行分析。
在 5543 例口腔切除术中，有 357 例为 OT，包括 336 例良性肿瘤（94.1%）和 21 例恶性肿瘤。在牙源性恶性肿瘤中，18 个病变（85.7%）为初发，3 个病变（14.3%）为先前分类为良性肿瘤的复发。高发年龄组为中老年人（90.4%），中位年龄为 42 岁。男性略占优势（1.3:1）。下颌是受影响最严重的部位，但所有复发性病例均在上颌诊断为造釉细胞瘤（n=2，66.6%）和原发性骨内癌（n=1，33.3%）。
对 MOT 的相对频率进行回顾性分析，并记录良性 OT 异常复发为恶性的情况，可增强我们对 OT 行为的认识，并需要进行适当的治疗和临床随访。
