Department of Colorectal Surgery, Bristol Royal Infirmary, University Hospitals, Bristol, UK.
Colorectal Dis. 2012 Apr;14(4):453-7. doi: 10.1111/j.1463-1318.2011.02682.x.
Concerns exist regarding laparoscopic rectal cancer surgery due to increased rates of open conversion, complications and circumferential resection margin positivity. This study reports medium-term results from consecutive unselected cases in a single surgeon series.
The results of laparoscopic total mesorectal excision (TME) for rectal cancer over a 9-year period within the context of an evolving 'enhanced recovery protocol' (ERP) were reviewed from analysis of a prospectively maintained database.
One hundred and fifty patients (91 male, median age 69 years, median BMI 26) underwent laparoscopic TME over 9 years. Median follow up was 28.5 months (range 0-88). Sixteen (10.6%) patients underwent neoadjuvant radiotherapy. Six (4.0%) required open conversion and 13 (9.0%) had an anastomotic leakage. The proportion of Dukes stages were: A, 33.3%; B, 30.7%; C, 31.3%; D, 4.7%. Five (3.3%) patients had an R1 and one an R2 resection. Median length of postoperative stay was 6 days. Three (2.0%) patients died within 30 days. Four (2.7%) developed local recurrence and 14 (9.3%) developed distant metastases. Predicted 5-year disease-free and overall survival rates by Kaplan-Meier analysis were 85.8% and 78.7%, respectively.
Laparoscopic TME surgery can safely be offered to unselected patients with rectal cancer with excellent medium-term results.
由于腹腔镜直肠癌手术中转开腹率、并发症和环周切缘阳性率增加,人们对此类手术存在担忧。本研究报告了单外科医生系列中连续未选择病例的中期结果。
在不断发展的“强化康复方案”(ERP)背景下,从前瞻性维护的数据库中分析了腹腔镜全直肠系膜切除术(TME)治疗直肠癌 9 年期间的结果。
150 例患者(91 例男性,中位年龄 69 岁,中位 BMI 26)接受了 9 年的腹腔镜 TME。中位随访时间为 28.5 个月(范围 0-88)。16 例(10.6%)患者接受了新辅助放疗。6 例(4.0%)需要中转开腹,13 例(9.0%)发生吻合口漏。Dukes 分期为:A 期 33.3%;B 期 30.7%;C 期 31.3%;D 期 4.7%。5 例(3.3%)患者有 R1 切除,1 例有 R2 切除。术后平均住院时间为 6 天。3 例(2.0%)患者在 30 天内死亡。4 例(2.7%)发生局部复发,14 例(9.3%)发生远处转移。Kaplan-Meier 分析预测的 5 年无病生存率和总生存率分别为 85.8%和 78.7%。
腹腔镜 TME 手术可安全地应用于未选择的直肠癌患者,具有良好的中期结果。