Day Andrew, Smith Ralph, Jourdan Iain, Rockall Tim
Minimal Access Therapy Training Unit, Postgraduate Medical School, University of Surrey, Guildford, UK.
Surg Laparosc Endosc Percutan Tech. 2012 Apr;22(2):e98-101. doi: 10.1097/SLE.0b013e318245d574.
Laparoscopic colonic resection for cancer is becoming well established within the surgical community. However, the current evidence for laparoscopic total mesorectal excision (TME) is scanty but does point toward a potential for improved short-term outcomes and oncological equivalency to open resection.
Patients undergoing laparoscopic TME for rectal cancer in 1 hospital between October 2003 and December 2010 were analyzed. Data were collated from a prospective database. Survival analysis was calculated using the Kaplan-Meier method.
79 patients were analyzed (96.3% of all TMEs). There was a median length of stay of 5 days, with no postoperative mortality. The 5-year overall survival was 70% and the 5-year disease-free survival was 65.5%. There was a conversion rate of 10.1%. The 5-year overall survival for completed laparoscopic cases was 70.6% versus 62.5% for converted cases (P=0.041).
There seems to be increasing evidence that laparoscopic TME is equivalent to open TME for rectal cancer. Conversion may be deleterious to overall survival.
腹腔镜结肠癌切除术在外科领域正逐渐得到广泛认可。然而,目前关于腹腔镜全直肠系膜切除术(TME)的证据较少,但确实表明其有可能改善短期预后并在肿瘤学方面与开放手术相当。
对2003年10月至2010年12月期间在1家医院接受腹腔镜TME治疗直肠癌的患者进行分析。数据来自前瞻性数据库。采用Kaplan-Meier方法进行生存分析。
共分析了79例患者(占所有TME手术的96.3%)。中位住院时间为5天,无术后死亡病例。5年总生存率为70%,5年无病生存率为65.5%。中转率为10.1%。完成腹腔镜手术病例的5年总生存率为70.6%,中转病例为62.5%(P = 0.041)。
越来越多的证据表明,腹腔镜TME治疗直肠癌与开放TME相当。中转手术可能对总生存率有害。