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未选择的直肠癌患者行低位前切除术并预防性回肠造口术,可在强化康复方案下安全管理。

Unselected rectal cancer patients undergoing low anterior resection with defunctioning ileostomy can be safely managed within an Enhanced Recovery Programme.

机构信息

Royal Bournemouth and Christchurch NHS Foundation Trust, Bournemouth Hospital, Castle Lane East, Bournemouth, BH7 7DW, UK.

出版信息

Tech Coloproctol. 2013 Feb;17(1):73-8. doi: 10.1007/s10151-012-0886-6. Epub 2012 Aug 31.

DOI:10.1007/s10151-012-0886-6
PMID:22936593
Abstract

BACKGROUND

An increasing body of evidence supports the application of the Enhanced Recovery Programme (ERP) to colorectal surgery. Some institutions have reported an association between ERP failure and low rectal cancer surgery. We present the results that we achieved by applying the ERP to low anterior resections for tumours within 6 cm of the anal verge, with a view to determining the validity and safety of applying the ERP to this patient group.

METHODS

A multimodal ERP, based on Kehlet's model, was introduced in January 2007 and applied to all patients undergoing elective resections. Patients having a low anterior resection for a rectal cancer less than 6 cm from the anal verge between January 2007 and August 2011 were retrospectively identified from a prospectively maintained database. Individual patient record review was performed.

RESULTS

Twenty consecutive patients (12 males) were identified. Median total postoperative length of stay (LOS), including readmission, was 8 days (mean 10.7, range 4-47 days), with 2 readmissions and no deaths. When surgery was uncomplicated, median LOS was 5 days (mean 5.8, range 4-12 days, n = 11), whereas LOS increased when a complication occurred, with a median of 12 days (mean 16.6, range 8-47 days, n = 9) [p = 0.001].

CONCLUSIONS

The ERP can safely be applied to this high-risk patient group. When no complication occurs, LOS of 5 days can be expected. When a complication is encountered, LOS is prolonged (12 days), but this is acceptable compared with the current national median LOS in the United Kingdom of 11 days for all rectal cancer surgery (at any height) with a stoma.

摘要

背景

越来越多的证据支持将强化康复方案(ERP)应用于结直肠手术。一些机构报告称,ERP 失败与低位直肠癌手术有关。我们报告了在距离肛门边缘 6cm 以内的肿瘤行低位前切除术时应用 ERP 的结果,旨在确定该患者群体应用 ERP 的有效性和安全性。

方法

基于 Kehlet 模型的多模式 ERP 于 2007 年 1 月引入,并应用于所有接受择期切除术的患者。从 2007 年 1 月至 2011 年 8 月,我们从一个前瞻性维护的数据库中回顾性地确定了距离肛门边缘小于 6cm 的直肠癌行低位前切除术的患者。对每个患者的记录进行单独审查。

结果

确定了 20 例连续患者(12 例男性)。包括再入院在内的总术后住院时间(LOS)中位数为 8 天(平均 10.7 天,范围 4-47 天),有 2 例再入院,无死亡。当手术无并发症时,中位 LOS 为 5 天(平均 5.8 天,范围 4-12 天,n=11),而当发生并发症时,LOS 延长至 12 天(平均 16.6 天,范围 8-47 天,n=9)[p=0.001]。

结论

ERP 可安全应用于该高危患者群体。当无并发症发生时,预计 LOS 为 5 天。当发生并发症时,LOS 延长(12 天),但与英国目前所有直肠癌手术(任何高度)造口术的全国中位 LOS(11 天)相比是可以接受的。

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本文引用的文献

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Surg Endosc. 2012 Feb;26(2):442-50. doi: 10.1007/s00464-011-1897-5. Epub 2011 Oct 20.
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Case-matched series of enhanced versus standard recovery pathway in minimally invasive colorectal surgery.微创结直肠手术中强化与标准康复路径的病例匹配系列研究。
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Laparoscopic total mesorectal excision can be performed on a nonselective basis in patients with rectal cancer with excellent medium-term results.
爱尔兰全国集中化项目后直肠癌手术当天入院的实施。
Ir J Med Sci. 2019 Aug;188(3):765-769. doi: 10.1007/s11845-018-1904-0. Epub 2018 Oct 6.
腹腔镜全直肠系膜切除术可在直肠癌患者中进行非选择性手术,具有极好的中期结果。
Colorectal Dis. 2012 Apr;14(4):453-7. doi: 10.1111/j.1463-1318.2011.02682.x.
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Enhanced recovery after surgery versus conventional perioperative care in rectal surgery.结直肠外科中术后加速康复与传统围手术期护理的比较
Dis Colon Rectum. 2011 Jul;54(7):833-9. doi: 10.1007/DCR.0b013e318216067d.
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[Risk factors for anastomotic leakage after anterior resection for rectal cancer].[直肠癌前切除术后吻合口漏的危险因素]
Nan Fang Yi Ke Da Xue Xue Bao. 2011 May;31(5):908-10.
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Fast track surgery versus conventional recovery strategies for colorectal surgery.结直肠手术的快速康复外科与传统恢复策略对比
Cochrane Database Syst Rev. 2011 Feb 16(2):CD007635. doi: 10.1002/14651858.CD007635.pub2.
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Predicting the risk and diminishing the consequences of anastomotic leakage after anterior resection for rectal cancer.预测直肠癌前切除术后吻合口漏的风险并减轻其后果。
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