King's College Hospital Denmark Hill, London SE5 9RS, UK.
Clin Liver Dis. 2011 May;15(2):443-62, vii-x. doi: 10.1016/j.cld.2011.03.011.
Management of pediatric liver tumors has significantly improved over the last 2 decades. The management options for hepatocelluar carcinoma (HCC) are not well defined. In the pediatric context, the main clinical aims are to reduce chemotherapy toxicity (predominantly ototoxicity and nephrotoxicity) in children treated for hepatoblastoma and to investigate additional modes of treatment for HCC. An increasing number of children develop HCC in the background of chronic liver disease, and screening methods need to be better observed.
过去 20 年来，小儿肝脏肿瘤的治疗有了显著改善。肝细胞癌 (HCC) 的治疗选择尚未明确。在儿科领域，主要的临床目标是降低接受肝母细胞瘤治疗的儿童的化疗毒性（主要是耳毒性和肾毒性），并探索 HCC 的其他治疗模式。越来越多的儿童在慢性肝病的背景下患上 HCC，需要更好地观察筛查方法。
