Department of Clinical Chemistry, University of Eastern Finland, Eastern Finland Laboratory Centre, Kuopio, Finland.
Clin Chim Acta. 2011 Sep 18;412(19-20):1809-13. doi: 10.1016/j.cca.2011.06.004. Epub 2011 Jun 14.
The percentages of hypochromic red blood cells (%HYPOm) and cellular hemoglobin in reticulocytes (CHr) are suggested to be useful screening markers of iron deficiency. The aim of this study was to investigate the diagnostic accuracy of %HYPOm and CHr in differentiating iron deficiency anemia (IDA) and anemia of chronic disease (ACD).
The retrospective population consisted of 58 IDA patients, 129 ACD patients and 63 controls, on whom bone marrow examination and blood count with %HYPOm and CHr had been performed. Receiver operating characteristic (ROC) analyses with area under the ROC curves (AUC) were used as statistical tests.
AUCs for differentiating the groups using %HYPOm were as follows: IDA vs. controls 0.99, ACD vs. controls 0.85 and IDA vs. ACD 0.88. AUCs for CHr in distinguishing the groups were as follows: IDA vs. controls 0.95, ACD vs. controls 0.65 and IDA vs. ACD 0.83.
IDA and ACD patients were efficiently differentiated by using %HYPOm and CHr. Additionally, %HYPOm was higher and CHr was lower in IDA patients and in ACD patients than in controls. Thus, %HYPOm is higher and CHr is lower not only in absolute iron deficiency, but also when iron availability for erythropoiesis is restricted.
低色素红细胞（%HYPOm）和网织红细胞内的细胞血红蛋白（CHr）的百分比被认为是缺铁的有用筛选标志物。本研究旨在探讨%HYPOm 和 CHr 区分缺铁性贫血（IDA）和慢性病贫血（ACD）的诊断准确性。
回顾性人群包括 58 例 IDA 患者、129 例 ACD 患者和 63 例对照者，对这些患者进行了骨髓检查和血细胞计数以及%HYPOm 和 CHr 检测。使用接受者操作特征（ROC）分析和 ROC 曲线下面积（AUC）作为统计检验。
使用%HYPOm 区分组别的 AUC 如下：IDA 与对照组 0.99、ACD 与对照组 0.85 和 IDA 与 ACD 0.88。区分组别的 CHr 的 AUC 如下：IDA 与对照组 0.95、ACD 与对照组 0.65 和 IDA 与 ACD 0.83。
使用%HYPOm 和 CHr 可有效区分 IDA 和 ACD 患者。此外，IDA 患者和 ACD 患者的%HYPOm 较高，CHr 较低，而对照组患者的%HYPOm 较低，CHr 较高。因此，%HYPOm 升高和 CHr 降低不仅发生在绝对缺铁时，而且在红细胞生成的铁供应受到限制时也会发生。
