Internal Medicine 1, Hospital de Faro, Centro Hospitalar Universitário do Algarve, Rua Leão Penedo, Faro, 8000-386, Portugal.
Intensive Care Medicine 1, Hospital de Faro, Centro Hospitalar Universitário do Algarve, Rua Leão Penedo, Faro, 8000-386, Portugal.
Inflammation. 2018 Aug;41(4):1115-1127. doi: 10.1007/s10753-018-0739-1.
Inflammation is an adaptive process to the noxious stimuli that the human body is constantly exposed to. From the local inflammatory response to a full-blown systemic inflammation, a wide complex sequence of events occurs. Persistent immunosuppression and catabolism may ensue, until multiple organ failure finally sets in. And since clinically useful and specific biomarkers are lacking, diagnosis may come late. A thorough understanding of these events (how they begin, how they evolve, and how to modulate them) is imperative, but as yet poorly studied. This review aims to consolidate current knowledge of these events so that the management of these patients is not only evidence-based, but also built on an understanding of the inner workings of the human body in health and in disease.
炎症是人体对不断接触到的有害刺激的适应性过程。从局部炎症反应到全面的全身炎症，会发生一系列广泛而复杂的事件。持续的免疫抑制和分解代谢可能随之而来，直到最终发生多器官衰竭。由于缺乏临床有用和特定的生物标志物，诊断可能会很晚。彻底了解这些事件（它们如何开始、如何演变以及如何调节它们）至关重要，但目前研究不足。这篇综述旨在整合这些事件的现有知识，以便对这些患者的管理不仅基于证据，而且还建立在对健康和疾病状态下人体内部运作的理解之上。
