Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, PR China.
Oral Oncol. 2011 Aug;47(8):709-13. doi: 10.1016/j.oraloncology.2011.05.017.
Sox2 is a marker of embryonic stem cell pluripotency and plays an important role in tumor progression. However, Sox2 expression in oral tongue squamous cell carcinoma (OTSCC) and its correlation with patients' prognosis have not been investigated so far. In this study, we detected the expression of Sox2 in 82 patients with histologically node-negative (pN0) OTSCC by immunohistochemistry, and evaluated its correlation with clinicopatologic factors and disease prognosis. Sox2 positive expression was detected in 62.2% patients and showed a significant association with large tumor size. Survival analysis showed that patients with Sox2 positive expression had significantly poorer overall, cancer-specific and disease-free survivals than those with Sox2 negative expression at 5years after operation (P=0.004, 0.004 and 0.001, respectively). Multivariate analysis demonstrated that Sox2 positive expression was an independent prognosticator of unfavorable overall, cancer-specific and disease-free survivals (P=0.032, 0.035 and 0.011, respectively). According to our results, Sox2 positive expression was frequent in pN0 OTSCC and involved in tumor progression. The measurement of Sox2 expression may be helpful in predicting relapse and prognosis of patients with pN0 OTSCC.
Sox2 是胚胎干细胞多能性的标志物，在肿瘤进展中发挥重要作用。然而，Sox2 在口腔舌鳞状细胞癌（OTSCC）中的表达及其与患者预后的关系尚未得到研究。在这项研究中，我们通过免疫组织化学检测了 82 例组织学无淋巴结转移（pN0）OTSCC 患者 Sox2 的表达，并评估了其与临床病理因素和疾病预后的相关性。Sox2 阳性表达在 62.2%的患者中检测到，与肿瘤较大显著相关。生存分析显示，与 Sox2 阴性表达的患者相比，Sox2 阳性表达的患者在术后 5 年内的总生存率、癌症特异性生存率和无病生存率显著降低（P=0.004、0.004 和 0.001）。多因素分析表明，Sox2 阳性表达是总生存率、癌症特异性生存率和无病生存率不良的独立预后因素（P=0.032、0.035 和 0.011）。根据我们的结果，Sox2 阳性表达在 pN0 OTSCC 中很常见，参与肿瘤进展。Sox2 表达的测量可能有助于预测 pN0 OTSCC 患者的复发和预后。
