将心脏脉动模型嵌入到心力衰竭随访的心血管调节综合模型中。
Embedding a cardiac pulsatile model into an integrated model of the cardiovascular regulation for heart failure followup.
机构信息
INSERM U642 Rennes, F35000, France.
出版信息
IEEE Trans Biomed Eng. 2011 Oct;58(10):2982-6. doi: 10.1109/TBME.2011.2159715. Epub 2011 Jun 16.
Abstract
The analysis of followup data from patients suffering from heart failure is a difficult task, due to the complex and multifactorial nature of this pathology. In this paper, we present a coupled model, integrating a pulsatile heart into a model of the short to long-term regulations of the cardiovascular system. An interface method is proposed to couple these models, which present significantly different time scales. Results from a sensitivity analysis of the original and integrated models are proposed with simulations reproducing the main effects of the short- and long-term responses of an acute decompensated heart failure episode on a patient undergoing cardiac resynchronization therapy.
摘要
心力衰竭患者的随访数据分析是一项艰巨的任务，因为这种病理具有复杂和多因素的性质。在本文中，我们提出了一个耦合模型，将脉动心脏与心血管系统的短期到长期调节模型集成在一起。提出了一种接口方法来耦合这些模型，这些模型具有明显不同的时间尺度。提出了原始模型和集成模型的敏感性分析结果，并通过模拟再现了正在接受心脏再同步治疗的急性失代偿性心力衰竭患者的短期和长期反应的主要影响。
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