Kruchenko Zh A, Sachenko V V
Neirofiziologiia. 1990;22(3):327-36.
Peculiarities of spike responses of the sensorimotor cortex neurons and conditional activity induced by blockade of noradrenergic and serotoninergic inputs of the PF complex (CM-PF) have been studied in chronic experiments on cats with a preliminarily conditioned placing reaction to an auditory stimulus--a click. It is shown that an increase in the background activity of neurons of the sensorimotor cortex was caused by microinjections of obsidan, an adrenergic blocker, while depression--by microinjections of lysergoamid, a serotonin blocker. The effect of both blockers on the neuronal reactions evoked by conditional auditory stimulus was the same (depression). Both conditional placing and unconditional one were removed by partial blockade of monoaminergic inputs for 30-60 min. A conclusion is made that the character of the influence of the monoaminergic system on the sensorimotor cortex is determined not only by direct, but also by indirect influences due to neurons of the CM-PF complex of thalamic nuclei.
在对猫进行的慢性实验中，研究了感觉运动皮层神经元的锋电位反应特性以及由阻断丘脑后腹核-丘脑前核复合体（CM-PF）的去甲肾上腺素能和5-羟色胺能输入所诱发的条件性活动。该实验中，猫对听觉刺激——咔哒声预先建立了条件性放置反应。结果表明，肾上腺素能阻滞剂奥昔丹的微量注射导致感觉运动皮层神经元背景活动增加，而5-羟色胺阻滞剂麦角酰胺的微量注射则导致活动抑制。两种阻滞剂对条件性听觉刺激诱发的神经元反应的影响相同（均为抑制）。单胺能输入的部分阻断持续30 - 60分钟会消除条件性放置反应和非条件性放置反应。由此得出结论，单胺能系统对感觉运动皮层的影响特性不仅由直接影响决定，还由丘脑核CM-PF复合体神经元产生的间接影响决定。
