Storozhuk V M, Stezhka V V, Ivanova S F
Neirofiziologiia. 1990;22(5):680-8.
In chronic experiments on cats the influence of iontophoretic application of adrenomimetic ephedrin and beta-adrenoblocker obsidan (propranolol) on motor cortex neuron reactions following conditional stimuli was investigated under instrumental placing reaction. It was shown for a majority of neurons that the background impulse activity and reactions following conditional stimulation were suppressed by the influence of ephedrin and on the contrary were increased by obsidan application. It is concluded that there exists a consistent tonic suppressing influence of the noradrenergic system on background and evoked cortical neurons impulse activity in the natural state. It is supposed that noradrenergic influence temporal increase may serve as an important link in mechanisms of external inhibition during stress situations, aversive effects, and distractive external excitations.
在对猫进行的慢性实验中，研究了在工具性放置反应条件下，通过离子电渗法应用拟肾上腺素麻黄碱和β-肾上腺素能阻滞剂奥布西丹（普萘洛尔）对条件刺激后运动皮层神经元反应的影响。结果表明，对于大多数神经元而言，麻黄碱的作用会抑制背景冲动活动和条件刺激后的反应，相反，应用奥布西丹则会使其增加。得出的结论是，去甲肾上腺素能系统在自然状态下对背景及诱发的皮层神经元冲动活动存在持续的紧张性抑制作用。据推测，去甲肾上腺素能影响的暂时增加可能是应激状态、厌恶效应和分散性外部刺激期间外部抑制机制中的一个重要环节。
