Zalaudek Iris, Schmid Karin, Marghoob Ashfaq A, Scope Alon, Manzo Manuela, Moscarella Elvira, Malvehy Josep, Puig Susana, Pellacani Giovanni, Thomas Luc, Catricalà Caterina, Argenziano Giuseppe
Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8036, Graz, Austria.
Arch Dermatol. 2011 Jun;147(6):663-70. doi: 10.1001/archdermatol.2011.149.
To subclassify acquired nevi by dermoscopic pattern.
Cross-sectional study with consecutive enrollment.
Pigmented lesion clinics in referral academic medical centers.
Individuals older than 2 years undergoing total skin examination were consecutively recruited between October 1, 2008, and May 31, 2009, and, based on their age, assigned to 1 of 8 groups. For each patient, the location and dermoscopic pattern of all nevi on the torso were recorded. Nevi were dermoscopically subclassified as globular, reticular, mixed (reticular-globular) pattern with peripheral or central globules, or unspecified pattern.
Frequency of dermoscopic nevus subtypes stratified by patient age and location of the nevi.
A total of 5481 nevi in 480 individuals were evaluated. The number of all nevus subgroups, except for unspecified pattern nevi, significantly increased before and decreased after the fourth decade of life. Globular nevi were most prevalent on the upper trunk in children and adolescents; the number decreased consistently after the second decade of life. The reticular pattern was the most common nevus pattern after the second decade of life and the most common nevus subgroup on the upper and middle back. Although uncommon, central globular nevi also showed an age-dependent trend, similar to that of reticular nevi. Nevi with the peripheral globular pattern declined rapidly after the third decade of life and were no longer observed after the sixth decade. The number of unspecified pattern nevi was stable across all age groups.
Age, dermoscopic pattern, and location of nevi should be jointly considered when evaluating melanocytic lesions.
根据皮肤镜表现对获得性痣进行亚分类。
连续入组的横断面研究。
转诊学术医疗中心的色素沉着病变诊所。
2008年10月1日至2009年5月31日期间连续招募年龄大于2岁且接受全面皮肤检查的个体，并根据其年龄分为8组中的1组。对于每位患者，记录躯干上所有痣的位置和皮肤镜表现。痣在皮肤镜下被亚分类为球状、网状、混合（网状 - 球状）且有周边或中央球状的模式，或未明确模式。
按患者年龄和痣的位置分层的皮肤镜下痣亚型的频率。
共评估了480名个体的5481颗痣。除未明确模式的痣外，所有痣亚组的数量在生命的第四个十年之前显著增加，之后减少。球状痣在儿童和青少年的上躯干最为常见；在生命的第二个十年之后数量持续减少。网状模式是生命的第二个十年之后最常见的痣模式，也是上背部和中背部最常见的痣亚组。虽然不常见，但中央球状痣也显示出与网状痣相似的年龄依赖性趋势。周边球状模式的痣在生命的第三个十年之后迅速减少，在第六个十年之后不再观察到。未明确模式的痣数量在所有年龄组中保持稳定。
在评估黑素细胞病变时，应综合考虑年龄、皮肤镜表现和痣的位置。
