一种水溶性苝染料，与 17β-雌二醇键合：一种用于类固醇激素的新型荧光工具。
A water-soluble perylene dye functionalised with a 17β-estradiol: a new fluorescent tool for steroid hormones.
机构信息
División de Química Orgánica, Instituto de Bioingeniería, Universidad Miguel Hernández, Elche 03202, Spain.
出版信息
Chem Commun (Camb). 2011 Aug 7;47(29):8307-9. doi: 10.1039/c1cc10966a. Epub 2011 Jun 20.
PMID:21691637
Abstract
We have successfully been able to synthesise a specific estrogen receptor-directed biolabel based on a fluorescent water-soluble perylenebisimide, thus offering great potential for determining the presence of estrogen receptors in any kind of cell. Moreover, this synthetic strategy allows the preparation of other conjugates involved in the study of any kind of receptor, simply by selecting the appropriate agonist or antagonist.
摘要
我们已经成功地合成了一种基于荧光水溶性苝二酰亚胺的特定雌激素受体导向生物标记物，因此为确定任何类型的细胞中雌激素受体的存在提供了巨大的潜力。此外，这种合成策略允许通过选择适当的激动剂或拮抗剂来制备其他参与任何类型受体研究的缀合物。
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