Bissett D L, Chatterjee R, Hannon D P
Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239-8707.
Photodermatol Photoimmunol Photomed. 1990 Apr;7(2):56-62.
Albino hairless mice (Skh:HR-1) exposed chronically to suberythemal doses of ultraviolet radiation develop visible skin changes, histological alterations, and tumors. Topical treatment of mice with solutions of superoxide-scavenging antioxidants (such as alpha-tocopherol, ascorbic acid, propyl gallate and Trolox) prior to each UVB radiation exposure reduced significantly the severity of these events. Tocopherol esters and ascorbyl palmitate were not as effective as the parent compounds in providing protection. The data suggest a role for superoxide in UVB radiation-induced skin photoaging and the protective potential of superoxide scavengers. In contrast, the severity of UVA radiation-induced mouse skin damage was not reduced by topical application of the antioxidants tested here.
长期暴露于亚红斑剂量紫外线辐射的白化无毛小鼠（Skh:HR-1）会出现明显的皮肤变化、组织学改变和肿瘤。在每次紫外线B（UVB）辐射暴露前，用超氧化物清除抗氧化剂（如α-生育酚、抗坏血酸、没食子酸丙酯和曲洛克斯）溶液对小鼠进行局部治疗，可显著降低这些事件的严重程度。生育酚酯和抗坏血酸棕榈酸酯在提供保护方面不如母体化合物有效。数据表明超氧化物在UVB辐射诱导的皮肤光老化中起作用，以及超氧化物清除剂的保护潜力。相比之下，此处测试的抗氧化剂局部应用并未降低紫外线A（UVA）辐射诱导的小鼠皮肤损伤的严重程度。
