Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea.
STR Biotech Co., Ltd., Chuncheon 24232, Republic of Korea.
Int J Mol Med. 2019 Aug;44(2):559-568. doi: 10.3892/ijmm.2019.4242. Epub 2019 Jun 12.
Processed products from agricultural produce generate a large number of agricultural by‑products that contain a number of functional substances. These are often discarded owing to the lack of suitable processing methods. The present study investigated the anti‑photoaging properties of fermented rice bran (FRB), soybean cake (FSB) and sesame seed cake (FSC) on ultraviolet B (UVB)‑irradiated hairless mouse skin. Results indicated that the oral administration of FRB, FSB and FSC effectively inhibited the UVB irradiation‑induced expression of matrix metalloproteinase (MMP)‑2, MMP‑9, MMP‑3 and MMP‑13. Reverse transcription‑quantitative polymerase chain reaction results also demonstrated that FRB, FSB and FSC significantly inhibited the UVB‑induced expression of the genes encoding tumor necrosis factor‑α, inducible nitric oxide synthase, interleukin (IL)‑6 and IL‑1β when compared with the UVB‑vehicle group (P<0.05). Additionally, collagen degradation and mast cell infiltration were reduced in hairless mouse skin. Furthermore, UVB‑induced wrinkle formation was also significantly reduced in mouse skin compared with the UVB‑vehicle group (P<0.05). These results reveal that fermented agricultural by‑products may serve as potential functional materials with anti‑photoaging activities.
农产品加工产品产生了大量的农业副产品，其中含有许多功能性物质。由于缺乏合适的加工方法，这些物质往往被丢弃。本研究探讨了发酵米糠（FRB）、大豆饼（FSB）和芝麻饼（FSC）对紫外线 B（UVB）照射无毛小鼠皮肤的抗光老化特性。结果表明，FRB、FSB 和 FSC 的口服给药可有效抑制 UVB 照射诱导的基质金属蛋白酶（MMP）-2、MMP-9、MMP-3 和 MMP-13 的表达。逆转录-定量聚合酶链反应结果还表明，与 UVB 载体组相比，FRB、FSB 和 FSC 显著抑制了编码肿瘤坏死因子-α、诱导型一氧化氮合酶、白细胞介素（IL）-6 和 IL-1β 的基因的 UVB 诱导表达（P<0.05）。此外，毛发小鼠皮肤中的胶原降解和肥大细胞浸润减少。此外，与 UVB 载体组相比，UVB 诱导的小鼠皮肤皱纹形成也显著减少（P<0.05）。这些结果表明，发酵农业副产品可能是具有抗光老化活性的潜在功能材料。
