来曲唑治疗与自然周期控制性卵巢刺激患者的激素、卵泡和子宫内膜动力学。
Hormonal, follicular and endometrial dynamics in letrozole-treated versus natural cycles in patients undergoing controlled ovarian stimulation.
机构信息
Department of Obstetrics and Gynecology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
出版信息
Reprod Biol Endocrinol. 2011 Jun 21;9:83. doi: 10.1186/1477-7827-9-83.
Abstract
The objective of this study was to compare letrozole-stimulated cycles to natural cycles in 208 patients undergoing intrauterine insemination (IUI) between July of 2004 and January of 2007. Group I (n = 47) received cycle monitoring only (natural group), Group II (n = 125) received letrozole 2.5 mg/day on cycle days three to seven, and Group III (n = 36) received letrozole 5 mg/day on cycle days three to seven. There were no differences between the groups in endometrial thickness or P₄ on the day of hCG. Estradiol levels had higher variation in the second half of the follicular phase in both letrozole-treated groups compared to the control group. Estradiol per preovulatory follicle was similar in both letrozole cycles to that observed in the natural cycles. LH was lower on the day of hCG administration in the letrozole 2.5 mg/day group vs. the natural group. In summary, letrozole results in some minor changes in follicular, hormonal and endometrial dynamics compared to natural cycles. Increased folliculogenesis and pregnancy rates were observed in the letrozole-treated groups compared to the natural group. These findings need to be confirmed in larger, prospective studies.
摘要
本研究旨在比较 2004 年 7 月至 2007 年 1 月期间 208 例接受宫腔内人工授精（IUI）患者的来曲唑刺激周期与自然周期。I 组（n=47）仅接受周期监测（自然组），II 组（n=125）在周期第 3-7 天接受来曲唑 2.5mg/天，III 组（n=36）在周期第 3-7 天接受来曲唑 5mg/天。三组间内膜厚度或 hCG 日 P₄无差异。与对照组相比，在卵泡期后半期，两个来曲唑治疗组的雌二醇水平变化较大。每个促排卵卵泡的雌二醇在来曲唑周期与自然周期中相似。与自然组相比，来曲唑 2.5mg/天组 hCG 日 LH 水平较低。总之，与自然周期相比，来曲唑导致卵泡、激素和子宫内膜动力学的一些轻微变化。与自然组相比，来曲唑治疗组的卵泡生成和妊娠率增加。这些发现需要在更大的前瞻性研究中得到证实。
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