来曲唑或枸橼酸氯米酚作为一线治疗排卵障碍性不孕：一场辩论。
Letrozole or clomiphene citrate as first line for anovulatory infertility: a debate.
机构信息
Reproductive Medicine Unit, Christian Medical College Hospital, Vellore 632004, Tamil Nadu, India.
出版信息
Reprod Biol Endocrinol. 2011 Jun 21;9:86. doi: 10.1186/1477-7827-9-86.
Abstract
Clomiphene citrate has been traditionally used as the drug of choice in treating women with anovulatory infertility. In the last decade letrozole, an aromatase inhibitor has emerged as alternative ovulation induction agent. Literature confirms that letrozole has a definitive role in anovulatory women who have not responded to the clomiphene therapy. However its role as an alternative to clomiphene as first line therapy continues to be debated. Although it is probable that the overall benefits of letrozole surpass clomiphene citrate, currently available data does not confirm this view. There is need for large well-designed trials.
摘要
枸橼酸氯米酚传统上被用作治疗排卵障碍性不孕妇女的首选药物。在过去的十年中，芳香化酶抑制剂来曲唑已成为另一种排卵诱导药物。文献证实，来曲唑在对枸橼酸氯米酚治疗无反应的排卵障碍妇女中具有明确的作用。然而，它作为一线治疗药物替代枸橼酸氯米酚的作用仍存在争议。尽管来曲唑的总体益处可能超过枸橼酸氯米酚，但目前尚无数据证实这一观点。需要进行大型精心设计的试验。
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