Department of Infectious Diseases, Alfred Hospital, Melbourne, Australia.
J Acquir Immune Defic Syndr. 2011 Sep 1;58(1):60-3. doi: 10.1097/QAI.0b013e318227f8dd.
Food insecurity is highly prevalent in HIV-infected populations, and analyses utilizing multiple assessments of food security to predict CD4 change are lacking. Five hundred Ninety-two patients with ≥ 4 food security assessments were followed prospectively. In the final model, for patients using antiretroviral therapy, increases in CD4 counts were on average 99.5 cells less for individuals with at least 1 episode of food insecurity compared with those consistently food secure (P < 0.001). Other sociodemographic factors were not predictive. Repeated assessments of food security are potent predictors of treatment response notwithstanding antiretroviral therapy use. Potential mechanisms for this association are proposed.
食物不安全在 HIV 感染者中非常普遍，利用多次食物安全评估来预测 CD4 变化的分析还很缺乏。592 名至少有 4 次食物安全评估的患者进行了前瞻性随访。在最终模型中，对于使用抗逆转录病毒疗法的患者，与那些一直有食物保障的个体相比，至少有 1 次食物不安全经历的个体的 CD4 计数平均减少 99.5 个细胞（P<0.001）。其他社会人口统计学因素没有预测作用。尽管使用了抗逆转录病毒疗法，但食物安全的反复评估是治疗反应的有力预测指标。提出了这种关联的潜在机制。
