用于小干扰 RNA 递送的共轭聚合物纳米颗粒。
Conjugated polymer nanoparticles for small interfering RNA delivery.
机构信息
Department of Chemistry and Biochemistry, Florida International University, 11200 SW 8th St., Miami, FL 33199, USA.
出版信息
Chem Commun (Camb). 2011 Aug 7;47(29):8370-2. doi: 10.1039/c1cc10991j. Epub 2011 Jun 22.
PMID:21695337
Abstract
Loosely aggregated conjugated polymer nanoparticles (CPNs) were used as nontoxic and efficient small interfering RNA (siRNA) delivery vehicles with delivery visualization. A significant down regulation (94%) of a target gene was achieved by transfection of HeLa cells with the CPNs/siRNA complexes, supporting CPN as a promising siRNA delivery carrier.
摘要
松散聚集的共轭聚合物纳米粒子 (CPNs) 可用作无毒且高效的小干扰 RNA (siRNA) 递药载体，并具有递药可视化功能。CPNs/siRNA 复合物转染 HeLa 细胞后，靶基因的下调幅度达到 94%，这表明 CPN 是一种很有前途的 siRNA 递药载体。
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