用于生物医学应用的共轭聚合物纳米粒子作为荧光探针的简便且宽范围尺寸调节
Facile and wide-range size tuning of conjugated polymer nanoparticles for biomedical applications as a fluorescent probe.
作者信息
Nakamura Noriko, Tanaka Nobuaki, Ohta Seiichi
机构信息
Institute of Engineering Innovation, The University of Tokyo 2-11-16 Yayoi, Bunkyo-ku Tokyo 113-8656 Japan
Department of Chemical System Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 Japan.
出版信息
RSC Adv. 2022 Apr 14;12(19):11606-11611. doi: 10.1039/d1ra09101h. eCollection 2022 Apr 13.
Conjugated polymer nanoparticles (Pdots) are expected to be novel bioimaging and sensing probes. However, the size tuning required to control biological interactions has not been well established. Herein, we achieved a size-tunable synthesis of Pdots ranging from 30 to 200 nm by controlling the hydrolysis rate of the stabilising agent and evaluated their cellular imaging properties.
共轭聚合物纳米颗粒（Pdots）有望成为新型的生物成像和传感探针。然而，控制生物相互作用所需的尺寸调节尚未得到很好的确立。在此，我们通过控制稳定剂的水解速率实现了尺寸可调的Pdots合成，其尺寸范围为30至200纳米，并评估了它们的细胞成像特性。
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