Facultad de Bioanálisis, Universidad Veracruzana, Escuela de Medicina, Universidad Cristóbal Colón, Veracruz, Veracruz, Mexico.
J Physiol Biochem. 2011 Dec;67(4):595-604. doi: 10.1007/s13105-011-0106-2. Epub 2011 Jun 22.
The fatty acid profile of hepatocytes and adipocytes is determined by the composition of the dietary lipids. It remains unclear which fatty acid components contribute to the development or reduction of insulin resistance. The present work examined the fatty acid composition of both tissues in sucrose-induced obese rats receiving fish oil to determine whether the effect of dietary (n-3) polyunsaturated fatty acids (PUFAs) on the reversion of metabolic syndrome in these rats is associated to changes in the fatty acid composition of hepatocyte and adipocyte membrane lipids. Animals with metabolic syndrome were divided into a corn-canola oil diet group and a fish oil diet group, and tissues fatty acids composition were analyzed after 6 weeks of dietary treatment. Fatty acid profiles of the total membrane lipids were modified by the fatty acid composition of the diets fed to rats. N-3 PUFAs levels in animals receiving the fish oil diet plus sucrose in drinking water were significantly higher than in animals under corn-canola oil diets. It is concluded that in sucrose-induced obese rats, consumption of dietary fish oil had beneficial effects on the metabolic syndrome and that such effects would be conditioned by the changes in the n-3 PUFAs composition in hepatic and adipose tissues because they alter membrane properties and modify the type of substrates available for the production of active lipid metabolites acting on insulin resistance and obesity.
肝细胞和脂肪细胞的脂肪酸谱由饮食脂质的组成决定。目前尚不清楚哪些脂肪酸成分有助于发展或减少胰岛素抵抗。本研究检查了蔗糖诱导肥胖大鼠的肝细胞和脂肪细胞的脂肪酸组成，以确定饮食（n-3）多不饱和脂肪酸（PUFAs）对这些大鼠代谢综合征逆转的影响是否与肝细胞和脂肪细胞膜脂质脂肪酸组成的变化有关。将患有代谢综合征的动物分为玉米油饮食组和鱼油饮食组，并在饮食治疗 6 周后分析组织的脂肪酸组成。动物饮食中脂肪酸的组成改变了总膜脂的脂肪酸谱。在饮用含蔗糖的鱼油饮食的动物中，n-3 PUFAs 的水平明显高于玉米油饮食的动物。结论是，在蔗糖诱导的肥胖大鼠中，饮食中摄入鱼油对代谢综合征有有益的影响，这种影响将受到肝脏和脂肪组织中 n-3 PUFAs 组成变化的调节，因为它们改变了膜的性质，并改变了可用于产生作用于胰岛素抵抗和肥胖的活性脂质代谢物的底物类型。
