游离脂肪酸受体 4 信号转导可减轻心脏代谢疾病。
Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease.
机构信息
Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota.
Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania.
出版信息
Physiology (Bethesda). 2022 Nov 1;37(6):311-322. doi: 10.1152/physiol.00007.2022. Epub 2022 Aug 9.
Abstract
A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-polyunsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.
摘要
肥胖症和代谢综合征患病率的上升，促进了全身炎症的发生，这是心血管代谢疾病增加的基础。游离脂肪酸受体 4 是长链脂肪酸（如 ω3-多不饱和脂肪酸（ω3-PUFA））的营养传感器，可减轻代谢疾病并缓解炎症。临床试验表明 ω3-PUFA 具有心脏保护作用，本综述讨论了 ω3-PUFA、游离脂肪酸受体 4 和减轻心血管代谢疾病之间的机制联系。
相似文献
1
Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease.游离脂肪酸受体 4 信号转导可减轻心脏代谢疾病。
Physiology (Bethesda). 2022 Nov 1;37(6):311-322. doi: 10.1152/physiol.00007.2022. Epub 2022 Aug 9.
2
ω3-Polyunsaturated fatty acids for heart failure: Effects of dose on efficacy and novel signaling through free fatty acid receptor 4.用于治疗心力衰竭的ω-3多不饱和脂肪酸：剂量对疗效的影响以及通过游离脂肪酸受体4的新信号传导
J Mol Cell Cardiol. 2017 Feb;103:74-92. doi: 10.1016/j.yjmcc.2016.12.003. Epub 2016 Dec 14.
3
Omega-3 polyunsaturated fatty acids protect peritoneal mesothelial cells from hyperglycolysis and mesothelial-mesenchymal transition through the FFAR4/CaMKKβ/AMPK/mTOR signaling pathway.ω-3 多不饱和脂肪酸通过 FFAR4/CaMKKβ/AMPK/mTOR 信号通路保护腹膜间皮细胞免受高糖酵解和间皮-间充质转化。
Int Immunopharmacol. 2024 Feb 15;128:111561. doi: 10.1016/j.intimp.2024.111561. Epub 2024 Jan 22.
4
Endogenously generated omega-3 fatty acids attenuate vascular inflammation and neointimal hyperplasia by interaction with free fatty acid receptor 4 in mice.内源性生成的ω-3脂肪酸通过与小鼠游离脂肪酸受体4相互作用减轻血管炎症和内膜增生。
J Am Heart Assoc. 2015 Apr 6;4(4):e001856. doi: 10.1161/JAHA.115.001856.
5
Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids.ω3 多不饱和脂肪酸的营养基因组学与营养遗传学。
Prog Mol Biol Transl Sci. 2012;108:75-112. doi: 10.1016/B978-0-12-398397-8.00004-6.
6
High fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis-inactivated Δ6-fatty acid desaturase-deficient mouse.高脂肪/高胆固醇饮食不会引起ω3 和 ω6 多不饱和脂肪酸合成失活的 Δ6-脂肪酸去饱和酶缺陷小鼠的动脉粥样硬化。
Mol Metab. 2021 Dec;54:101335. doi: 10.1016/j.molmet.2021.101335. Epub 2021 Sep 14.
7
Dietary and supplemental long-chain omega-3 fatty acids as moderators of cognitive impairment and Alzheimer's disease.饮食和补充长链欧米伽-3 脂肪酸作为认知障碍和阿尔茨海默病的调节剂。
Eur J Nutr. 2022 Mar;61(2):589-604. doi: 10.1007/s00394-021-02655-4. Epub 2021 Aug 15.
8
Mechanistic insights into cardiovascular protection for omega-3 fatty acids and their bioactive lipid metabolites.ω-3脂肪酸及其生物活性脂质代谢产物对心血管保护作用的机制研究
Eur Heart J Suppl. 2020 Oct 6;22(Suppl J):J3-J20. doi: 10.1093/eurheartj/suaa115. eCollection 2020 Oct.
9
FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids.ω-3脂肪酸的抗炎和胰岛素增敏作用并不需要FFAR4（GPR120）信号传导。
Mediators Inflamm. 2016;2016:1536047. doi: 10.1155/2016/1536047. Epub 2016 Nov 24.
10
Dietary ω3-and ω6-Polyunsaturated fatty acids reconstitute fertility of Juvenile and adult Fads2-Deficient mice.膳食中的ω3和ω6多不饱和脂肪酸可恢复幼年和成年Fads2基因缺陷小鼠的生育能力。
Mol Metab. 2020 Jun;36:100974. doi: 10.1016/j.molmet.2020.100974. Epub 2020 Mar 17.
引用本文的文献
1
FFAR4 Deficiency Increases Necrotic Cores in Advanced Lesions of ApoE Mice-Brief Report.FFAR4基因缺陷增加载脂蛋白E基因敲除小鼠晚期病变中的坏死核心——简要报告
Arterioscler Thromb Vasc Biol. 2025 May;45(5):675-682. doi: 10.1161/ATVBAHA.124.322371. Epub 2025 Mar 6.
2
Eicosapentaenoic acid and Arachidonic acid Protection Against Left Ventricle Pathology: the Multi-Ethnic Study of Atherosclerosis.二十碳五烯酸和花生四烯酸对左心室病变的保护作用：动脉粥样硬化的多民族研究
medRxiv. 2024 Jun 5:2024.06.05.24308494. doi: 10.1101/2024.06.05.24308494.
3
Free fatty acid receptor 4 in cardiac myocytes ameliorates ischemic cardiomyopathy.心肌细胞中的游离脂肪酸受体4可改善缺血性心肌病。
bioRxiv. 2024 Apr 15:2024.04.12.589280. doi: 10.1101/2024.04.12.589280.
4
Diet-derived and diet-related endogenously produced palmitic acid: Effects on metabolic regulation and cardiovascular disease risk.膳食来源和与膳食相关的内源性产生的棕榈酸：对代谢调节和心血管疾病风险的影响。
J Clin Lipidol. 2023 Sep-Oct;17(5):577-586. doi: 10.1016/j.jacl.2023.07.005. Epub 2023 Jul 28.
5
Free fatty acids and peripheral blood mononuclear cells (PBMC) are correlated with chronic inflammation in obesity.游离脂肪酸与外周血单个核细胞与肥胖症的慢性炎症相关。
Lipids Health Dis. 2023 Jul 4;22(1):93. doi: 10.1186/s12944-023-01842-y.
本文引用的文献
1
Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association.《心脏病与卒中统计-2022 更新：美国心脏协会报告》。
Circulation. 2022 Feb 22;145(8):e153-e639. doi: 10.1161/CIR.0000000000001052. Epub 2022 Jan 26.
2
The Anti-Atherosclerotic Action of FFAR4 Agonist TUG-891 in ApoE-Knockout Mice Is Associated with Increased Macrophage Polarization towards M2 Phenotype.FFAR4 激动剂 TUG-891 在载脂蛋白 E 敲除小鼠中的抗动脉粥样硬化作用与巨噬细胞向 M2 表型极化增加有关。
Int J Mol Sci. 2021 Sep 9;22(18):9772. doi: 10.3390/ijms22189772.
3
Effects of omega-3 polyunsaturated fatty acids supplementation for patients with cardiovascular disease risks: a dose-response meta-analysis.补充ω-3多不饱和脂肪酸对心血管疾病风险患者的影响：一项剂量反应荟萃分析。
Am J Transl Res. 2021 Aug 15;13(8):8526-8539. eCollection 2021.
4
Effect of omega-3 fatty acids on cardiovascular outcomes: A systematic review and meta-analysis.ω-3脂肪酸对心血管结局的影响：一项系统评价和荟萃分析。
EClinicalMedicine. 2021 Jul 8;38:100997. doi: 10.1016/j.eclinm.2021.100997. eCollection 2021 Aug.
5
A possible explanation for the contrasting results of REDUCE-IT vs. STRENGTH: cohort study mimicking trial designs.REDUCE-IT 与 STRENGTH 结果对比的可能解释：模拟试验设计的队列研究。
Eur Heart J. 2021 Dec 14;42(47):4807-4817. doi: 10.1093/eurheartj/ehab555.
6
Effects of dietary eicosapentaenoic acid and docosahexaenoic acid supplementation on metabolic syndrome: A systematic review and meta-analysis of data from 33 randomized controlled trials.膳食二十碳五烯酸和二十二碳六烯酸补充对代谢综合征的影响：来自 33 项随机对照试验数据的系统评价和荟萃分析。
Clin Nutr. 2021 Jul;40(7):4538-4550. doi: 10.1016/j.clnu.2021.05.025. Epub 2021 Jun 5.
7
Unraveling the Role of 12- and 20- HETE in Cardiac Pathophysiology: G-Protein-Coupled Receptors, Pharmacological Inhibitors, and Transgenic Approaches.解析 12-和 20-HETE 在心脏病理生理学中的作用：G 蛋白偶联受体、药理学抑制剂和转基因方法。
J Cardiovasc Pharmacol. 2021 Jun 1;77(6):707-717. doi: 10.1097/FJC.0000000000001013.
8
Protective effects of a unique combination of nutritionally active ingredients on risk factors and gene expression associated with atherosclerosis in C57BL/6J mice fed a high fat diet.在高脂肪饮食喂养的 C57BL/6J 小鼠中，一种独特的营养活性成分组合对与动脉粥样硬化相关的风险因素和基因表达的保护作用。
Food Funct. 2021 Apr 21;12(8):3657-3671. doi: 10.1039/d0fo02867c. Epub 2021 Mar 31.
9
Free fatty acid receptor 4 responds to endogenous fatty acids to protect the heart from pressure overload.游离脂肪酸受体 4 对内源性脂肪酸作出响应，从而保护心脏免受压力超负荷的影响。
Cardiovasc Res. 2022 Mar 16;118(4):1061-1073. doi: 10.1093/cvr/cvab111.
10
Omega-3 fatty acids supplementation on major cardiovascular outcomes: an umbrella review of meta-analyses of observational studies and randomized controlled trials.补充ω-3脂肪酸对主要心血管结局的影响：观察性研究和随机对照试验的荟萃分析的综合评价
Eur Rev Med Pharmacol Sci. 2021 Feb;25(4):2079-2092. doi: 10.26355/eurrev_202102_25113.
Zotero 插件