German Sport University Cologne, Outpatient Clinic for Sports Traumatology and Public Health Consultation, Cologne, Germany. t.schiff
Int J Sports Med. 2011 Sep;32(9):683-7. doi: 10.1055/s-0031-1279732. Epub 2011 Jun 21.
The aim of this study was to examine the effects of strength and endurance training on myostatin mRNA in the vastus lateralis muscle of healthy and physically active humans. 21 healthy and physically active sports students (static and dynamic knee extensor strength 33 ± 4.5 N/kgBW; 1 185 ± 170 W, respectively; maximum oxygen uptake 52.5 ± 8 ml/kgBW/min) were recruited and randomly assigned to a moderate endurance training group (n=7), a strength training group (n=7) and a control group (n=7). Muscle biopsies were taken from the vastus lateralis muscle 3-5 days before the start as well as at the end of the 12 weeks' training period. Exercise-specific functional improvements after moderate endurance training and strength training were measured for submaximal endurance and for static and dynamic strength of the knee extensor muscles. None of the myostatin mRNA values showed significant pre-post differences or group-specific differences. These results are in contrast to data with sedentary subjects, suggesting that myostatin is necessary for adaptations of skeletal muscle to exercise stress. We conclude that functional improvements after moderate endurance training and strength training can occur without alterations in myostatin mRNA in physically active humans.
本研究旨在探讨力量和耐力训练对健康、活跃的人体股外侧肌肌抑素 mRNA 的影响。21 名健康、活跃的运动学生（静态和动态伸膝力量分别为 33 ± 4.5 N/kgBW 和 1 185 ± 170 W；最大摄氧量为 52.5 ± 8 ml/kgBW/min）被招募并随机分配到中等耐力训练组（n=7）、力量训练组（n=7）和对照组（n=7）。在开始训练前 3-5 天和 12 周训练结束时，从股外侧肌采集肌肉活检。测量中等耐力训练和力量训练后股四头肌亚最大耐力和静态及动态伸膝力量的特定运动功能改善情况。肌抑素 mRNA 值均未显示出显著的前后差异或组间差异。这些结果与久坐人群的数据形成对比，表明肌抑素对于骨骼肌适应运动应激是必要的。我们得出结论，在健康活跃的人群中，中等耐力训练和力量训练后的功能改善可以在肌抑素 mRNA 没有改变的情况下发生。
