Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran.
Translational Physiology Research Group, School of Life Sciences, University of Westminster, London, UK.
Eur J Appl Physiol. 2019 Sep;119(9):1921-1931. doi: 10.1007/s00421-019-04180-z. Epub 2019 Jun 25.
Due to the mechanistic role of myostatin and follistatin in modulating muscle mass, shifts in the follistatin to myostatin ratio (F:M) may help explain changes in muscular size in response to resistance training (RT). The present study examined whether differential responses in follistatin and myostatin occur based on the amount of active musculature in a RT program in middle-aged men.
Forty middle-aged men (age = 46.5 ± 3.1 years) were randomly assigned to 1 of 4 groups, upper-body RT (UB; n = 10), lower-body RT (LB; n = 10), combined RT (UB + LB; n = 10) or control (C; n = 10). The training protocol consisted of three exercise sessions per week for 8 weeks. Blood samples were obtained at baseline and 48 h after the final session of the training program.
Muscle mass significantly increased (p < 0.05) following UB = 0.76 ± 0.46 kg, LB = 0.90 ± 0.29 kg, UB + LB = 1.38 ± 0.70 kg, compared to no changes after control. Serum follistatin increased in the LB = 0.24 ± 0.06 ng mL, UB = 0.27 ± 0.17 ng mL, UB + LB = 0.50 ± 0.18 ng mL, while serum myostatin decreased in the LB = - 0.11 ± 0.08 ng mL and UB + LB = - 0.34 ± 0.23 ng mL, but not UB = 0.07 ± 0.16 ng mL. Further, change in concentration following training was larger between UB + LB and either LB or UB alone for both follistatin and myostatin.
Both UB and LB increase muscle mass and alter the F: M ratio; however, the change in these endocrine markers is approximately twice as large if UB and LB is combined. The endocrine response to RT of myostatin and follistatin may depend on the volume of muscle mass activated during training.
由于肌肉生长抑制素和卵泡抑素在调节肌肉质量方面的机制作用，卵泡抑素与肌肉生长抑制素比值（F:M）的变化可能有助于解释抗阻训练（RT）引起的肌肉大小变化。本研究旨在探讨在中年男性的 RT 计划中，基于主动肌量的不同，卵泡抑素和肌肉生长抑制素是否会出现不同的反应。
40 名中年男性（年龄=46.5±3.1 岁）被随机分配到 4 个组中的 1 个，分别为上半身 RT（UB；n=10）、下半身 RT（LB；n=10）、综合 RT（UB+LB；n=10）或对照组（C；n=10）。训练方案包括每周 3 次运动，共 8 周。在训练计划的最后一次训练后 48 小时采集血液样本。
UB=0.76±0.46kg、LB=0.90±0.29kg、UB+LB=1.38±0.70kg，肌肉质量显著增加（p<0.05），而对照组没有变化。血清卵泡抑素在 LB=0.24±0.06ng·mL、UB=0.27±0.17ng·mL、UB+LB=0.50±0.18ng·mL 中增加，而血清肌肉生长抑制素在 LB=-0.11±0.08ng·mL 和 UB+LB=-0.34±0.23ng·mL 中降低，但 UB=0.07±0.16ng·mL 没有变化。此外，与单独的 UB 或 LB 相比，UB+LB 训练后两种激素的浓度变化都更大。
UB 和 LB 均可增加肌肉质量并改变 F:M 比值；然而，如果 UB 和 LB 相结合，这些内分泌标志物的变化大约是两倍。肌肉生长抑制素和卵泡抑素对 RT 的内分泌反应可能取决于训练中激活的肌肉质量体积。
