Chunpongthong Pongsak, Ko Zin Zin Win Ko, Yeekian Chuenrutai, Luvira Viravarn, Pitisuttithum Punnee
Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand.
J Med Assoc Thai. 2011 Jun;94(6):664-70.
To study the outcomes of antituberculosis treatment in HIV/AIDS patients on antiretroviral therapy (ART).
This retrospective cohort study was performed by reviewing medical records of 166 patients co-infected with tuberculosis (TB) and HIV in a hospital in Thailand seen between January 2005 and February 2008. These patients were treated with both antituberculosis (antiTB) and antiretroviral drugs (ART) and were followed for 18 months after the beginning of antiTB.
Total 166 HIV patients with TB on ART and anti tuberculosis drugs were analyzed. The median age of patients was 36 years (20-72). Sixty-nine (41.6%) patients had pulmonary TB and 97 (58.4%) disseminated TB. Among them, 127 (76.5%) were cured and 15 (9.0%) had unsuccessful treatment. Median time for successful treatment was 10.8 months (6-32) during 18 months follow-up. There was no statistically significant difference in outcome of tuberculosis between the NVP and EFV base regimens in combination with rifampicin (5.4% vs. 10.8%, p = 0.751).
Majority of HIV patients on ARTwith tuberculosis were successfully treated with antiTB drugs with median time of 10.8 months and no significant difference ofadverse events reported between NVP and EFV
研究接受抗逆转录病毒治疗（ART）的HIV/AIDS患者的抗结核治疗结果。
本回顾性队列研究通过查阅2005年1月至2008年2月期间泰国一家医院166例合并结核（TB）和HIV感染患者的病历进行。这些患者同时接受抗结核（antiTB）和抗逆转录病毒药物（ART）治疗，并在开始抗结核治疗后随访18个月。
共分析了166例接受ART和抗结核药物治疗的HIV合并TB患者。患者的中位年龄为36岁（20 - 72岁）。69例（41.6%）患者患有肺结核，97例（58.4%）患有播散性结核。其中，127例（76.5%）治愈，15例（9.0%）治疗失败。在18个月的随访期间，成功治疗的中位时间为10.8个月（6 - 32个月）。奈韦拉平（NVP）和依非韦伦（EFV）基础方案联合利福平治疗的结核病结局无统计学显著差异（5.4%对10.8%，p = 0.751）。
大多数接受ART且合并结核的HIV患者通过抗结核药物成功治愈，中位时间为10.8个月，NVP和EFV报告的不良事件无显著差异
