艾滋病毒相关结核病患者开始抗逆转录病毒治疗的最佳时间：在结核病诊断之前还是之后？
Optimum time to start antiretroviral therapy in patients with HIV-associated tuberculosis: before or after tuberculosis diagnosis?
机构信息
Desmond Tutu HIV Centre, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
出版信息
AIDS. 2011 Apr 24;25(7):1003-6. doi: 10.1097/QAD.0b013e328345ee32.
WHO policy states that tuberculosis (TB) should be diagnosed and treated before starting antiretroviral treatment (ART). However, during the pre-ART screening period, diagnosing or excluding TB can be a lengthy process and may cause undesirable delays in ART initiation. In this observational study from South Africa, we report that initiation of ART before TB treatment in patients with delayed diagnoses of culture-positive prevalent TB was not associated with adverse clinical, immunological or virological outcomes during 12-month follow-up.
世界卫生组织的政策指出，在开始抗逆转录病毒治疗（ART）之前，应该诊断和治疗肺结核（TB）。然而，在 ART 前筛查期间，诊断或排除 TB 可能是一个漫长的过程，可能导致 ART 启动的不必要延迟。在南非的这项观察性研究中，我们报告称，在培养阳性的潜伏性肺结核患者延迟诊断后，在开始 ART 之前开始治疗 TB，并不会在 12 个月的随访期间导致不良的临床、免疫或病毒学结局。
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