Retinal Imaging Research and Reading Center (RIRRC), Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
Am J Ophthalmol. 2011 Sep;152(3):400-405.e2. doi: 10.1016/j.ajo.2011.02.024. Epub 2011 Jun 21.
To investigate relationship between macular sensitivity and retinal thickness in diabetic macular edema (DME).
Prospective observational study.
settings: University-based retina practice. patients: Twenty-two eyes of 11 patients with DME. procedure: Fundus microperimetry and retinal thickness tomography were performed simultaneously using an automatic fundus perimetry/tomography system. main outcome measures: Quantification of macular sensitivity, fixation pattern, and relationship between macular sensitivity and retinal thickness.
Fixation stability revealed that 21 eyes (95.4%) had stable fixation (>75% within central 2 degrees of point of fixation) and 1 eye (4.5%) had relatively unstable fixation (<75% of fixation points located within 2 degrees, >75% located within 4 degrees). Evaluation of fixation location revealed that 15 eyes (68.2%) had central (>50% of fixation points within 0.5 mm of fovea), 3 eyes (13.6%) pericentral (25% to 50% within 0.5 mm of fovea), and 4 eyes (18.2%) eccentric (<25% of fixation points within 0.5 mm of fovea) fixation location. Macular sensitivity increased by an average of 0.03 decibel (dB) (95% confidence interval [CI]: 0.00, 0.06) per 1-micron (μm) increase in retinal thickness for thickness values ≤280 μm measured with the OPKO/OTI spectral-domain OCT. The macular sensitivity decreased by an average 0.05 dB (95% CI: -0.08, -0.02) per 1-μm increase in thickness for thickness values >280 μm.
In this pilot study, the majority of eyes with DME had stable, central fixation. Macular sensitivity varied depending on the thickness of the retina. Additional studies are needed to determine the role of microperimetry in eyes with DME.
研究糖尿病性黄斑水肿（DME）中黄斑敏感性与视网膜厚度之间的关系。
前瞻性观察研究。
地点：大学附属医院的视网膜科。患者：11 例 DME 患者的 22 只眼。程序：使用自动眼底照相/断层扫描系统同时进行眼底微视野检查和视网膜厚度断层扫描。主要观察指标：黄斑敏感性定量、固视模式以及黄斑敏感性与视网膜厚度之间的关系。
固视稳定性显示，21 只眼（95.4%）固视稳定（>中央 2 度注视点的 75%），1 只眼（4.5%）固视相对不稳定（<75%的注视点位于中央 2 度内，>75%位于中央 4 度内）。固视位置评估显示，15 只眼（68.2%）为中心固视（>50%的注视点位于黄斑中心 0.5mm 内），3 只眼（13.6%）为旁中心固视（黄斑中心 0.5mm 内的 25%~50%），4 只眼（18.2%）为偏心固视（黄斑中心 0.5mm 内的注视点<25%）。在视网膜厚度值≤280μm 时，用 OPKO/OTI 光谱域 OCT 测量，视网膜厚度每增加 1μm，黄斑敏感性平均增加 0.03dB（95%可信区间：0.00，0.06）。在视网膜厚度值>280μm 时，黄斑敏感性平均降低 0.05dB（95%可信区间：-0.08，-0.02），每增加 1μm 厚度。
在这项初步研究中，大多数 DME 眼具有稳定的中心固视。黄斑敏感性随视网膜厚度而变化。需要进一步研究来确定微视野检查在 DME 眼中的作用。
