Mount Sinai School of Medicine, Seaver Autism Center, Department of Psychiatry, New York, New York, 10029, USA.
Trends Cogn Sci. 2011 Jul;15(7):301-9. doi: 10.1016/j.tics.2011.05.002. Epub 2011 Jun 21.
Building on animal research, the past decade has witnessed a surge of interest in the effects of oxytocin on social cognition and prosocial behavior in humans. This work has generated considerable excitement about identifying the neurochemical underpinnings of sociality in humans, and discovering compounds to treat social functioning deficits. Inspection of the literature, however, reveals that the effects of oxytocin in the social domain are often weak and/or inconsistent. We propose that this literature can be informed by an interactionist approach in which the effects of oxytocin are constrained by features of situations and/or individuals. We show how this approach can improve understanding of extant research, suggest novel mechanisms through which oxytocin might operate, and refine predictions about oxytocin pharmacotherapy.
基于动物研究，过去十年见证了人们对催产素对人类社会认知和亲社会行为影响的兴趣激增。这项工作引发了人们对识别人类社会性的神经化学基础以及发现治疗社交功能障碍的化合物的极大兴趣。然而，对文献的检查表明，催产素在社会领域的影响通常较弱和/或不一致。我们提出，这种方法可以通过一种相互作用的方法来提供信息，在这种方法中，催产素的作用受到情况和/或个体特征的限制。我们展示了这种方法如何能够改进对现有研究的理解，提出催产素可能发挥作用的新机制，并对催产素药物治疗做出更精确的预测。
