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评估 [18F]FDG-PET/CT 和 [68Ga]DOTATOC-PET/CT 在鉴别典型和非典型肺类癌中的作用。

Evaluation of the role of [18F]FDG-PET/CT and [68Ga]DOTATOC-PET/CT in differentiating typical and atypical pulmonary carcinoids.

机构信息

Department of General Surgery, All India Institute of Medical Sciences, New Delhi, India.

出版信息

Cancer Imaging. 2011 Jun 15;11(1):70-5. doi: 10.1102/1470-7330.2011.0010.

DOI:10.1102/1470-7330.2011.0010
PMID:21697027
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3205752/
Abstract

Pulmonary carcinoids are histologically classified into typical and atypical. It is important to identify these preoperatively for treatment planning and prognosis. Structural imaging cannot conclusively differentiate between them. The aim of this study was to assess the possibility of differentiating the 2 variants using [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) and [68Ga]1,4,7,10-tetraazacyclododecane-N(I-IIII)-tetraacetic acid-(D)-Phe1-Thy3-octreotide (DOTATOC)-PET/CT. The imaging results of 20 patients with pulmonary carcinoids (13 typical, 7 atypical) on [18F]FDG-PET/CT and [68Ga]DOTATOC-PET/CT were assessed retrospectively. Six typical carcinoids failed to reveal significant uptake on [18F]FDG-PET/CT. All the atypical carcinoids revealed significant uptake on the [18F]FDG-PET/CT that was higher than that in typical carcinoids (standardized uptake value (SUV)max, 2.9-8.4, P = 0.001). The SUVmax in typical carcinoids on [68Ga]DOTATOC-PET/CT was significantly higher (SUVmax, 8.8-66) compared with atypical carcinoids (SUVmax, 1.1-18.5, P = 0.002). Ratios of SUVmax on [68Ga]DOTATOC-PET/CT to that on [18F]FDG-PET/CT were significantly higher (P < 0.001) in typical carcinoids compared with atypical carcinoids. The different uptake patterns on [18F]FDG and [68Ga]DOTATOC-PET/CT. and the ratio of SUVmax may be helpful in differentiating between typical and atypical carcinoids.

摘要

肺类癌组织学上分为典型和非典型。术前识别这些对治疗计划和预后很重要。结构成像不能明确区分它们。本研究旨在评估使用 [18F]氟脱氧葡萄糖（FDG）-正电子发射断层扫描（PET）/计算机断层扫描（CT）和 [68Ga]1,4,7,10-四氮杂环十二烷-N（I-IIII）-四乙酸-（D）-Phe1-Thy3-奥曲肽（DOTATOC）-PET/CT 区分这两种变体的可能性。回顾性分析了 20 例肺类癌患者（13 例典型，7 例非典型）的 [18F]FDG-PET/CT 和 [68Ga]DOTATOC-PET/CT 成像结果。6 例典型类癌在 [18F]FDG-PET/CT 上未见明显摄取。所有非典型类癌在 [18F]FDG-PET/CT 上均有明显摄取，高于典型类癌（标准化摄取值（SUV）max，2.9-8.4，P = 0.001）。[68Ga]DOTATOC-PET/CT 上典型类癌的 SUVmax 明显更高（SUVmax，8.8-66），而非典型类癌的 SUVmax 明显更低（SUVmax，1.1-18.5，P = 0.002）。[68Ga]DOTATOC-PET/CT 与 [18F]FDG-PET/CT 的 SUVmax 比值在典型类癌中明显更高（P < 0.001），而非典型类癌中明显更低。[18F]FDG 和 [68Ga]DOTATOC-PET/CT 摄取模式不同，SUVmax 比值有助于区分典型和非典型类癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7875/3205752/3d6fb1785d3b/ci11001002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7875/3205752/3943a86ab849/ci11001001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7875/3205752/3d6fb1785d3b/ci11001002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7875/3205752/3943a86ab849/ci11001001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7875/3205752/3d6fb1785d3b/ci11001002.jpg

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