Center for Comparative Medicine and Translational Research, Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA.
J Neurosci. 2011 Jun 22;31(25):9368-82. doi: 10.1523/JNEUROSCI.0171-11.2011.
Establishment of a neural stem cell niche in the postnatal subependymal zone (SEZ) and the rostral migratory stream (RMS) is required for postnatal and adult neurogenesis in the olfactory bulbs (OB). We report the discovery of a cellular lineage in the SEZ-RMS-OB continuum, the specification of which is dependent on the expression of the forkhead transcription factor Foxj1 in mice. Spatially and temporally restricted Foxj1+ neuronal progenitors emerge during embryonic periods, surge during perinatal development, and are active only for the first few postnatal weeks. We show that the development of the unique Foxj1-derived lineage is dependent on Foxj1 expression and is required for overall postnatal neurogenesis in the OB. Strikingly, the production of neurons from Foxj1+ progenitors significantly declines after the early postnatal weeks, but Foxj1-derived neurons in the OB persist during adult periods. For the first time, our study identifies the time- and region-specific activity of a perinatal progenitor domain that is required for transition and progression of OB neurogenesis from the embryonic-to-postnatal periods.
在嗅球（OB）中，建立神经干细胞龛在产后室管膜下区（SEZ）和额状迁移流（RMS）中是产后和成年神经发生所必需的。我们报告了在 SEZ-RMS-OB 连续体中发现了一个细胞谱系，其特征取决于叉头转录因子 Foxj1 在小鼠中的表达。在胚胎期出现空间和时间上受限的 Foxj1+神经元祖细胞，在围产期发育过程中激增，并仅在出生后的前几周活跃。我们表明，独特的 Foxj1 衍生谱系的发育依赖于 Foxj1 表达，并且是 OB 中整体产后神经发生所必需的。引人注目的是，Foxj1+祖细胞产生的神经元在出生后的早期几周后显著减少，但 Foxj1 衍生的 OB 神经元在成年期持续存在。我们的研究首次确定了围产期祖细胞结构域的时间和区域特异性活性，该结构域是 OB 神经发生从胚胎期到出生后的过渡和进展所必需的。
