Puche Adam C, Baker Harriet
Department of Anatomy and Neurobiology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
J Mol Histol. 2007 Dec;38(6):513-5. doi: 10.1007/s10735-007-9140-3. Epub 2007 Sep 19.
This special issue of the Journal of Molecular Histology is devoted to the unique phenomena of migration and adult neurogenesis observed in the olfactory system. Neural progenitors migrate from the olfactory placode and epithelium (OE) into the central nervous system (CNS) and from the forebrain ventricular region to the olfactory bulb (OB). Not unexpectedly, there are a number of controversies with regard to the mechanisms regulating these phenomena in both developing and adult animals. One especially controversial issue common to both the peripheral (OE) and central (OB) systems is the identity of the slowly dividing multipotent stem cell and the mechanisms regulating the lineage specification of these progenitors which eventually differentiate into neurons and glia. Nine contributions from leading laboratories address these and other issues with respect to progenitors and their integration into OE and OB circuitry in several species.
《分子组织学杂志》的这一特刊致力于探讨在嗅觉系统中观察到的独特的迁移现象和成年神经发生。神经祖细胞从嗅基板和上皮（OE）迁移到中枢神经系统（CNS），并从前脑脑室区域迁移到嗅球（OB）。不出所料，在发育中和成年动物中，关于调节这些现象的机制存在许多争议。外周（OE）和中枢（OB）系统共有的一个特别有争议的问题是缓慢分裂的多能干细胞的身份以及调节这些祖细胞谱系特化的机制，这些祖细胞最终分化为神经元和神经胶质细胞。来自顶尖实验室的九篇论文探讨了与祖细胞及其整合到几种物种的OE和OB神经回路相关的这些及其他问题。
