Department of Psychiatry, Graduate School of Medical Sciences, Kitasato University, 1–15–1 Kitasato, Minami-ku, Sagamihara, Kanagawa, Japan.
Ind Health. 2011;49(4):427-33. doi: 10.2486/indhealth.ms1257. Epub 2011 Jun 21.
Although autonomic nervous system activity is reportedly related to diurnal glucose tolerance impairment, the relationship with glucose tolerance during sleep is unclear. Since work styles have recently diversified, it is important to assess the effect of sleep on workers' health. Elucidation of the relationship between autonomic nervous system activity during sleep and glucose tolerance in workers may facilitate preventive measures against diabetes using non-pharmacological means (e.g., sleep hygiene education, relaxation techniques and stress management). We examined whether autonomic nervous system activity during sleep is related to fasting glucose or glycated hemoglobin (HbA1c) in individuals with either normal or impaired fasting glucose tolerance. The subjects were 77 apparently healthy Japanese workers with normal or impaired fasting glucose. We used high frequency (HF) and the ratio of low frequency to high frequency (LF/HF) obtained by pulse wave analysis to estimate autonomic nervous system activity. The data were analyzed using a generalized estimating equation adjusted for potential confounders (age, gender, engagement in shift work, sleep duration, and body mass index). Fasting glucose was significantly negatively related to HF, the parasympathetic component during sleep. Our results suggest that parasympathetic activity during sleep is associated with fasting glucose in apparently healthy Japanese workers.
虽然自主神经系统活动据报道与日间葡萄糖耐量受损有关，但与睡眠期间葡萄糖耐量的关系尚不清楚。由于工作方式最近已经多样化，评估睡眠对工人健康的影响很重要。阐明睡眠期间自主神经系统活动与工人葡萄糖耐量之间的关系，可能有助于通过非药物手段（例如，睡眠卫生教育、放松技术和压力管理）预防糖尿病。我们研究了睡眠期间自主神经系统活动与空腹血糖或糖化血红蛋白（HbA1c）在空腹血糖正常或受损的个体中的关系。研究对象为 77 名空腹血糖正常或受损的日本健康工人。我们使用脉搏波分析获得的高频（HF）和低频与高频的比值（LF/HF）来估计自主神经系统活动。使用广义估计方程调整潜在混杂因素（年龄、性别、轮班工作、睡眠时间和体重指数）对数据进行分析。空腹血糖与睡眠期间副交感成分的 HF 呈显著负相关。我们的结果表明，睡眠期间的副交感活动与日本健康工人的空腹血糖有关。
