Ochiai Ryuji, Tomonobu Kazuichi, Ikushima Ippei
Biological Science Laboratories Kao Corporation Tokyo Japan.
Health Care Food Research Laboratories Kao Corporation Tokyo Japan.
Food Sci Nutr. 2018 Oct 19;6(8):2530-2536. doi: 10.1002/fsn3.861. eCollection 2018 Nov.
Chlorogenic acids (CGAs) are found in abundance in coffee beans and have numerous health benefits. This study investigated the effect of CGAs extracted from coffee beans on fatigue and sleep in healthy participants. This crossover study involved 16 men (aged 30-54 years) who were daytime workers with weekends off work. The participants were randomized into two groups: One group was given a placebo beverage, and the other was given an active beverage containing 300 mg of CGAs. The test beverages were consumed for 13 days starting on a Sunday. The evaluation criteria were feelings of fatigue and sleep quality, sleep-related indices recorded by an activity meter, and biomarkers. Feelings of fatigue and sleep-related indices during the first (first half of week 1) and second (second half of week 2) halves of the consumption periods were compared. Within the first half of week 1, no differences in feelings of fatigue were observed between the groups. However, during the second half of week 2, fatigue upon awakening and sleep quality in the active group were significantly improved compared with those in the placebo group. Sleep efficiency and total nocturnal awakening time were significantly deteriorated in the second half of week 2 compared with the first half of week 1 in the placebo group. Furthermore, significant differences in these indices were observed between the two groups in the second half of week 2. These results suggest that the daily consumption of CGA-containing beverages may improve fatigue upon awakening and sleep quality.
绿原酸（CGAs）在咖啡豆中大量存在，对健康有诸多益处。本研究调查了从咖啡豆中提取的绿原酸对健康参与者疲劳和睡眠的影响。这项交叉研究涉及16名男性（年龄在30 - 54岁之间），他们是白天工作、周末休息的上班族。参与者被随机分为两组：一组饮用安慰剂饮料，另一组饮用含有300毫克绿原酸的活性饮料。从周日开始，测试饮料连续饮用13天。评估标准包括疲劳感、睡眠质量、活动计记录的睡眠相关指标以及生物标志物。比较了饮用期前半段（第1周前半段）和后半段（第2周后半段）的疲劳感和睡眠相关指标。在第1周前半段，两组之间未观察到疲劳感的差异。然而，在第2周后半段，与安慰剂组相比，活性组醒来时的疲劳感和睡眠质量有显著改善。在安慰剂组中，第2周后半段的睡眠效率和夜间总觉醒时间与第1周前半段相比显著恶化。此外，在第2周后半段，两组在这些指标上存在显著差异。这些结果表明，每日饮用含绿原酸的饮料可能会改善醒来时的疲劳感和睡眠质量。
