Takimoto Hidemi, Hayashi Fumi, Kusama Kaoru, Kato Noriko, Yoshiike Nobuo, Toba Mikayo, Ishibashi Tomoko, Miyasaka Naoyuki, Kubota Toshiro
Department of Health Promotion, National Institute of Public Health, 2-3-6 Minami, Wako, Saitama, Japan.
J Nutr Sci Vitaminol (Tokyo). 2011;57(2):130-7. doi: 10.3177/jnsv.57.130.
This study aimed to examine the association of fetal growth and elevated third trimester maternal serum folate due to folic acid (FA) supplement intake. Dietary intake, use of FA supplements, weight, and blood biomarkers of B-vitamins (serum folate, pyridoxal, vitamin B(12), and plasma total homocysteine) were observed in 33 healthy pregnant women at the third trimester (average gestational age 35 wk). Birth outcomes were assessed through hospital birth records. Infant anthropometry and maternal blood biomarkers were followed up at 1 mo postpartum. Fourteen women were taking FA supplements at the third trimester. Dietary intake was similar among FA users and non-users, but serum folate and pyridoxal were significantly higher in users (11.6±6.7 vs. 6.1±3.2 ng/mL, and 13.8±21.7 vs. 3.2±1.4 ng/mL, respectively). Plasma total homocystein (tHcy) was higher in non-users compared to users, but not significantly. Nine FA users and eight non-users had low serum vitamin B(12) values (<203 pg/mL). Nine FA users and all non-users had low serum pyridoxal values (<7.0 ng/mL). Infant birthweight was significantly lower in users compared to non-users (2,894±318 vs. 3,154±230 g). At 1 mo postpartum, infant weight and length were similar between FA users and non-users, but infant weight gain was larger in users. Higher serum folate values due to FA use in the third trimester was related to reduced fetal size. Excess FA under low vitamin B(6) and B(12) status may affect fetal growth.
本研究旨在探讨孕期补充叶酸（FA）导致孕晚期母体血清叶酸升高与胎儿生长之间的关联。观察了33名健康孕妇孕晚期（平均孕周35周）的饮食摄入、FA补充剂使用情况、体重以及B族维生素的血液生物标志物（血清叶酸、吡哆醛、维生素B12和血浆总同型半胱氨酸）。通过医院出生记录评估出生结局。在产后1个月对婴儿人体测量指标和母体血液生物标志物进行随访。14名女性在孕晚期服用FA补充剂。FA使用者和非使用者的饮食摄入相似，但使用者的血清叶酸和吡哆醛显著更高（分别为11.6±6.7 vs. 6.1±3.2 ng/mL，以及13.8±21.7 vs. 3.2±1.4 ng/mL）。非使用者的血浆总同型半胱氨酸（tHcy）高于使用者，但差异不显著。9名FA使用者和8名非使用者血清维生素B12值较低（<203 pg/mL）。9名FA使用者和所有非使用者血清吡哆醛值较低（<7.0 ng/mL）。与非使用者相比，使用者的婴儿出生体重显著更低（2,894±318 vs. 3,154±230 g）。在产后1个月，FA使用者和非使用者的婴儿体重和身长相似，但使用者的婴儿体重增加更大。孕晚期因使用FA导致的血清叶酸值升高与胎儿尺寸减小有关。在维生素B6和B12水平较低的情况下，过量的FA可能会影响胎儿生长。
