GENUD (Growth, Exercise, Nutrition and Development) Research Group, Health Sciences Faculty, University of Zaragoza, Zaragoza, Spain.
Public Health Nutr. 2013 Oct;16(10):1843-60. doi: 10.1017/S1368980012003953. Epub 2012 Sep 13.
To review evidence on the associations between vitamin B12 intake and its biomarkers, vitamin B12 intake and its functional health outcomes, and vitamin B12 biomarkers and functional health outcomes.
A systematic review was conducted by searching electronic databases, until January 2012, using a standardized strategy developed in the EURRECA network. Relevant articles were screened and sorted based on title and abstract, then based on full text, and finally included if they met inclusion criteria. A total of sixteen articles were included in the review.
Articles covered four continents: America (n 4), Europe (n 8), Africa (n 1) and Asia (n 3).
Population groups included healthy infants, children and adolescents, and pregnant and lactating women.
From the total number of 5815 papers retrieved from the initial search, only sixteen were eligible according to the inclusion criteria: five for infants, five for children and adolescents, and six for pregnant and lactating women.
Only one main conclusion could be extracted from this scarce number of references: a positive association between vitamin B12 intake and serum vitamin B12 in the infant group. Other associations were not reported in the eligible papers or the results were not provided in a consistent manner. The low number of papers that could be included in our systematic review is probably due to the attention that is currently given to research on vitamin B12 in elderly people. Our observations in the current systematic review justify the idea of performing well-designed studies on vitamin B12 in young populations.
综述维生素 B12 摄入量及其生物标志物、维生素 B12 摄入量与其功能性健康结果之间的关联，以及维生素 B12 生物标志物与功能性健康结果之间的关联的证据。
通过搜索电子数据库，直到 2012 年 1 月，使用 EURRECA 网络制定的标准化策略进行了系统评价。根据标题和摘要筛选和分类相关文章，然后根据全文进行筛选，最后如果符合纳入标准则纳入。共有 16 篇文章纳入综述。
文章涵盖了四大洲：美洲（n=4）、欧洲（n=8）、非洲（n=1）和亚洲（n=3）。
人群组包括健康婴儿、儿童和青少年以及孕妇和哺乳期妇女。
从最初搜索中检索到的 5815 篇论文中，只有 16 篇符合纳入标准：5 篇针对婴儿，5 篇针对儿童和青少年，6 篇针对孕妇和哺乳期妇女。
从这为数不多的参考文献中只能得出一个主要结论：婴儿组的维生素 B12 摄入量与血清维生素 B12 之间存在正相关。其他关联在合格论文中没有报道，或者结果没有以一致的方式提供。我们的系统评价中能够纳入的论文数量很少，可能是因为目前人们对老年人维生素 B12 研究的关注。我们在本次系统评价中的观察结果证实了在年轻人群中进行精心设计的维生素 B12 研究的想法。
