Department of Radiation Oncology, The Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA.
Int J Gynecol Cancer. 2011 Jul;21(5):941-4. doi: 10.1097/IGC.0b013e31821bca53.
Brachytherapy is an integral component of the curative treatment of locally advanced cervical cancer. Optimal applicator placement is associated with improvements in local control and treatment-related toxicity. Uterine perforation by the tandem is common and often undetected by orthogonal radiographs. The role of ultrasound in guiding tandem placement remains controversial.
A 55-year-old woman with International Federation of Gynecology and Obstetrics stage IIB cervix cancer underwent placement of a Fletcher-Suit-Delcos tandem and ovoids applicator. Postoperative computed tomography was used for treatment planning.
The applicator appeared to be appropriately placed on clinical exam and orthogonal radiographs. Postoperative computed tomography revealed the tandem had perforated the anterior uterine wall. In a second procedure, the tandem was placed correctly under intraoperative ultrasonography.
A review of the literature finds a relatively high rate of uterine perforation of the uterus that is undetected by orthogonal radiographs or clinical examination. Multiple reports support the use of real-time ultrasound for patients with especially challenging anatomy. As this report illustrates, uterine perforation is possible in any patient. Therefore, routine real-time ultrasonography should be considered for all uterine tandem insertions.
近距离放射治疗是局部晚期宫颈癌治疗的重要组成部分。最佳施源器放置与局部控制和治疗相关毒性的改善相关。子宫穿透是常见的,并且经常通过正交射线照相术未被检测到。超声在引导施源器放置中的作用仍然存在争议。
一名 55 岁的国际妇产科联合会(FIGO)IIB 期宫颈癌患者接受 Fletcher-Suit-Delcos 施源器和子宫内填充物施源器的放置。术后计算机断层扫描用于治疗计划。
临床检查和正交射线照相术显示施源器位置合适。术后计算机断层扫描显示施源器已穿透子宫前壁。在第二次手术中,在术中超声下正确放置了施源器。
文献回顾发现,子宫穿孔的发生率相对较高,正交射线照相术或临床检查无法检测到。多项报告支持对具有特别挑战性的解剖结构的患者使用实时超声。正如本报告所示,子宫穿孔可能发生在任何患者中。因此,应考虑对所有子宫施源器插入进行常规实时超声检查。